17543-58-7

Basic information

• Product Name: Z-P-FLUORO-PHE-OH
• Synonyms: CBZ-L-4-FLUOROPHENYLALANINE;CBZ-4-FLUORO-L-PHE;CBZ-(S)-2-AMINO-3-(4'-FLUOROPHENYL)PROPANOIC ACID;Z-PHE(P-F)-OH;Z-PHE(4-F)-OH;Z-P-FLUORO-PHENYLALANINE;Z-P-FLUORO-PHE-OH;Z-4-FLUORO-L-PHENYLALANINE
• CAS NO: 17543-58-7
• Molecular Formula: C₁₇H₁₆FNO₄
• Molecular Weight: 317.31
• Product Categories: Phenylalanine [Phe, F];Unusual Amino Acids;Z-Amino acid series
• Mol File: 17543-58-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 158-160℃ (ethyl acetate ligroine )
• Boiling Point: 515.754 °C at 760 mmHg
• Flash Point: 265.718 °C
• Appearance: /
• Density: 1.301 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Z-P-FLUORO-PHE-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Z-P-FLUORO-PHE-OH(17543-58-7)
• EPA Substance Registry System: Z-P-FLUORO-PHE-OH(17543-58-7)

Safety Data

• Hazardous Substances Data: 17543-58-7(Hazardous Substances Data)

Usage

General Description

Z-P-FLUORO-PHE-OH is a chemical compound that belongs to the class of organic compounds known as phenylalanine and derivatives. The structure of this compound is characterized by a phenylalanine or derivative therein, which is characterized by a phenylalanine moiety. Particularly, it is a peptide derivative and mainly used in biochemistry. This chemical is used in the advancement of inhibitory activity modelling against cathepsin L, a lysosomal cysteine protease involved in several pathological conditions. The compound is also used in different research contexts due to its reactivity and biological role.

Upstream product

• 1132-68-9 L-4-fluorophenylalanine 
• 501-53-1 benzyl chloroformate 
• 141971-11-1 Z-DL-Phe(4F)OMe 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 49759-49-1 2-Benzyloxycarbonylamino-2-(4-fluoro-benzyl)-malonic acid diethyl ester 
• 49864-41-7 2-Benzyloxycarbonylamino-2-(4-fluoro-benzyl)-malonic acid monoethyl ester 
• 3005-66-1 diethyl 2-benzyloxycarbonylaminomalonate 
• 51-65-0 4-Fluorophenylalanine 
• 394210-36-7 4-(4-fluoro-benzyl)-2,5-dioxo-oxazolidine-3-carboxylic acid benzyl ester 
• 49759-55-9 ethyl N-benzyloxycarbonyl-4-fluorophenylalaninate 
• 127862-81-1 Z-DL-Phe(4F)-OCH₂CF₃ 

Downstream Products

• 188196-22-7 L-tyrosyl-D-alanyl-p-fluoro-L-phenylalanyl-L-phenylalaninamide 
• 169243-86-1 (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-fluorophenyl)propanoic acid 
• 325958-70-1 {4-tert-butoxycarbonylmethyl-1-[2-(4-carbamimidoyl-benzoylamino)-3-(4-fluoro-phenyl)-propionyl]-3-oxo-piperazin-2-yl}-acetic acid methyl ester 
• 501010-21-5 C₂₄H₃₂FN₅O₄ 
• 500783-06-2 C₄₃H₄₆FN₅O₄ 
• 500783-01-7 C₃₅H₃₃FN₄O 
• 500782-98-9 C₄₃H₃₇FN₄O₃ 
• 500782-95-6 C₁₉H₁₇FN₂O₃ 
• 892864-87-8 C₄₇H₄₂FN₅O₂ 
• 892864-86-7 C₄₃H₃₉BrFN₅O₂ 

Relevant articles and documents

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Compounds, compositions and methods for preventing, treating or curing a coronavirus, picornavirus, and/or Hepeviridae virus infection in human subjects or other animal hosts. Specific viruses that can be treated include enteroviruses. In one embodiment, the compounds can be used to treat an infection with a severe acute respiratory syndrome virus, such as human coronavirus 229E, SARS, MERS, SARS-CoV-1 (OC43), and SARS-CoV- 2. In another embodiment, the methods are used to treat a patient co-infected with two or more of these viruses, or a combination of one or more of these viruses and norovirus.

PEPTIDOMIMETICS FOR THE TREATMENT OF NOROVIRUS INFECTION

The present invention is directed to compounds, compositions and methods for preventing, treating or curing Norovirus infection in human subjects or other animal hosts.

Asymmetric synthesis of α-amino acids via cinchona alkaloid-catalyzed kinetic resolution of urethane-protected α-amino acid N-carboxyanhydrides

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