175278-22-5

Basic information

• Product Name: 4-Amino-3-(trifluoromethoxy)benzoic acid
• Synonyms: 4-Amino-3-(trifluoromethoxy)benzoic acid 97%;4-Amino-3-(trifluoromethoxy)benzoicacid97%;3-(TRIFLUOROMETHOXY)-4-AMINOBENZOICACID;4-Amine-3-(trifluoromethoxy)Benzoic acid;4-Carboxy-2-(trifluoromethoxy)aniline;BUTTPARK 83\07-32;4-AMINO-3-(TRIFLUOROMETHOXY)BENZOIC ACID;RARECHEM AL BO 0798
• CAS NO: 175278-22-5
• Molecular Formula: C₈H₆F₃NO₃
• Molecular Weight: 221.13
• Product Categories: Trifluoroanisole series;Carboxylic Acids;Phenyls & Phenyl-Het;Heterocyclic Compounds;Carboxylic Acids;Phenyls & Phenyl-Het;Fluorine series
• Mol File: 175278-22-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 168 °C
• Boiling Point: 303.2 °C at 760 mmHg
• Flash Point: 137.2 °C
• Appearance: /
• Density: 1.528 g/cm³
• Vapor Pressure: 0.00166mmHg at 25°C
• Refractive Index: 1.498
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.48±0.10(Predicted)
• CAS DataBase Reference: 4-Amino-3-(trifluoromethoxy)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-3-(trifluoromethoxy)benzoic acid(175278-22-5)
• EPA Substance Registry System: 4-Amino-3-(trifluoromethoxy)benzoic acid(175278-22-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-43
• Safety Statements: 22-36/37/39-37/39-26-36/37
• Hazardous Substances Data: 175278-22-5(Hazardous Substances Data)

Usage

Description

4-Amino-3-(trifluoromethoxy)benzoic acid is a chemical compound with the molecular formula C8H7F3NO3. It is a derivative of benzoic acid, featuring a trifluoromethoxy group at the third carbon and an amino group at the fourth carbon. 4-Amino-3-(trifluoromethoxy)benzoic acid is significant in the fields of chemistry and pharmaceutical research due to its versatile applications and potential therapeutic effects.

Uses

Used in Pharmaceutical and Chemical Synthesis Applications:
4-Amino-3-(trifluoromethoxy)benzoic acid is utilized as an intermediate in the synthesis of various pharmaceuticals and chemical compounds. Its unique structure allows for the creation of molecules with specific properties, making it a valuable building block in organic synthesis.
Used in Enzyme Inhibition:
4-Amino-3-(trifluoromethoxy)benzoic acid has potential therapeutic effects due to its ability to inhibit certain enzymes. By blocking the activity of these enzymes, 4-Amino-3-(trifluoromethoxy)benzoic acid can contribute to the development of treatments for various diseases and conditions.
Used in the Production of Pesticides:
4-Amino-3-(trifluoromethoxy)benzoic acid may have industrial applications in the production of pesticides. Its chemical properties can be harnessed to create effective and targeted pest control agents.
Used in the Production of Dyes:
4-Amino-3-(trifluoromethoxy)benzoic acid can also be used in the manufacturing of dyes. Its unique structure and reactivity make it suitable for the development of dyes with specific color characteristics and properties.

InChI:InChI=1/C8H5F3N2O/c9-8(10,11)14-7-3-6(13)2-1-5(7)4-12/h1-3H,13H2

Upstream product

• 1011531-66-0 4-amino-3-(trifluoromethoxy)benzoic acid methyl ester hydrochloride 

Downstream Products

• 1011531-66-0 4-amino-3-(trifluoromethoxy)benzoic acid methyl ester hydrochloride 
• 1090901-79-3 3-{3-[4-amino-3-(trifluoromethoxy)benzyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}hexanoic acid 
• 1378869-35-2 1-bromo-4-(bromomethyl)-2-(trifluoromethoxy)benzene 
• 1011531-67-1 (4-bromo-3-(trifluoromethoxy)phenyl)methanol 
• 1433280-40-0 4'-{2-[(2S,4S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-4-methylsulfanyl-pyrrolidin-2-yl]-1H-imidazol-4-yl}-2-trifluoromethoxy-biphenyl-4-carboxylic acid methyl ester 
• 957206-36-9 4-bromo-3-trifluoromethoxy-benzoic acid methyl ester 
• 1260742-02-6 ethyl 4-amino-3-(trifluoromethoxy)benzoate 
• 1403330-28-8 4-bromo-3-(trifluoromethoxy)benzamide 
• 457097-93-7 4-amino-3-trifluoromethoxybenzoic acid methyl ester 
• 1352621-31-8 [4-bromo-3-(trifluoromethoxy)phenyl](2-oxa-6-azaspiro[3.3]hept-6-yl)-methanone 
• 1352621-30-7 [4-bromo-3-(trifluoromethoxy)phenyl](morpholin-4-yl)methanone 
• 1352621-29-4 ethyl 4-bromo-3-(trifluoromethoxy)benzoate 
• 1352619-72-7 2-(4-fluorophenyl)-N-[4-(2-{[4-(morpholin-4-ylcarbonyl)-2-(trifluoromethoxy)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]acetamide 
• 1008769-87-6 4-bromo-3-(trifluoromethoxy)benzoic acid 

Relevant articles and documents

HETEROCYCLIC GPR40 MODULATORS

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.