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TAS 103, a novel anti-cancer agent, is designed to inhibit both topoisomerase (Topo) I and Topo II enzymes, which play a crucial role in DNA replication and transcription. By targeting these enzymes, TAS 103 can effectively interfere with the cancer cells' ability to divide and proliferate, making it a promising candidate for cancer treatment.

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  • 174634-09-4 Structure
  • Basic information

    1. Product Name: TAS 103
    2. Synonyms: TAS-103 (dihydrochloride);TAS-103(2HCl);TAS-103(BMS-247615);6-[[2-(Dimethylamino)ethyl]amino]-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one dihydrochloride;BMS-247615-2HCl
    3. CAS NO:174634-09-4
    4. Molecular Formula: C20H21Cl2N3O2
    5. Molecular Weight: 406.30564
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 174634-09-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 564°Cat760mmHg
    3. Flash Point: 294.9°C
    4. Appearance: /
    5. Density: g/cm3
    6. Vapor Pressure: 9.56E-13mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    9. Solubility: N/A
    10. CAS DataBase Reference: TAS 103(CAS DataBase Reference)
    11. NIST Chemistry Reference: TAS 103(174634-09-4)
    12. EPA Substance Registry System: TAS 103(174634-09-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 174634-09-4(Hazardous Substances Data)

174634-09-4 Usage

Uses

Used in Oncology:
TAS 103 is used as an anti-cancer agent for its ability to inhibit both topoisomerase I and II, which are essential enzymes in DNA replication and transcription. This inhibition disrupts the cancer cells' ability to divide and proliferate, making TAS 103 a potential treatment option for various types of cancer.
Used in Drug Development:
In the pharmaceutical industry, TAS 103 serves as a valuable compound for the development of new cancer therapies. Its dual inhibition of topoisomerase I and II provides a unique mechanism of action that can be further explored and optimized to improve the efficacy and safety of cancer treatments.
Used in Cancer Research:
TAS 103 is also utilized in cancer research to better understand the role of topoisomerase enzymes in cancer cell growth and proliferation. Studying the effects of TAS 103 on these enzymes can provide valuable insights into the development of novel cancer therapies and contribute to the advancement of cancer treatment strategies.

Check Digit Verification of cas no

The CAS Registry Mumber 174634-09-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,4,6,3 and 4 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 174634-09:
(8*1)+(7*7)+(6*4)+(5*6)+(4*3)+(3*4)+(2*0)+(1*9)=144
144 % 10 = 4
So 174634-09-4 is a valid CAS Registry Number.
InChI:InChI=1/C20H19N3O2.2ClH/c1-23(2)10-9-21-20-18-17(13-5-3-4-6-14(13)19(18)25)15-8-7-12(24)11-16(15)22-20;;/h3-8,11,21-22H,9-10H2,1-2H3;2*1H

174634-09-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-[2-(dimethylamino)ethylamino]-5H-indeno[2,1-c]quinoline-3,7-dione,dihydrochloride

1.2 Other means of identification

Product number -
Other names TAS-103

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:174634-09-4 SDS

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