17216-62-5

Basic information

• Product Name: DIETHYL 2-(2-CYANOETHYL)MALONATE
• Synonyms: Diethyl 2-cyanomalonate;Propanedioic acid, (2-cyanoethyl)-, diethyl ester;DIETHYL (2-CYANOETHYL)MALONATE;DIETHYL 2-(2-CYANOETHYL)MALONATE;2-(2-CYANOETHYL)MALONIC ACID DIETHYL ESTER;(2-CYANOETHYL)MALONIC ACID DIETHYL ESTER;TIMTEC-BB SBB000530;4,4-Bis(ethoxycarbonyl)butyronitrile~2-Cyanoethylmalonic acid diethyl ester
• CAS NO: 17216-62-5
• Molecular Formula: C₁₀H₁₅NO₄
• Molecular Weight: 213.23
• EINECS: 241-260-7
• Product Categories: C10 to C11;Carbonyl Compounds;Esters
• Mol File: 17216-62-5.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 115-118 °C2 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.078 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00238mmHg at 25°C
• Refractive Index: n20/D 1.436(lit.)
• Storage Temp.: 2-8°C
• PKA: 12.15±0.59(Predicted)
• BRN: 1790237
• CAS DataBase Reference: DIETHYL 2-(2-CYANOETHYL)MALONATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYL 2-(2-CYANOETHYL)MALONATE(17216-62-5)
• EPA Substance Registry System: DIETHYL 2-(2-CYANOETHYL)MALONATE(17216-62-5)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 36-26
• RIDADR: 3276
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 17216-62-5(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR COLORLESS TO LIGHT YELLOW LIQUID

InChI:InChI=1/C10H15NO4/c1-3-14-9(12)8(6-5-7-11)10(13)15-4-2/h8H,3-6H2,1-2H3

Upstream product

• 542-76-7 3-Chloropropionitrile 
• 105-53-3 diethyl malonate 
• 107-13-1 acrylonitrile 
• 1405679-69-7 diethyl 2-(3-(hydroxyimino)propyl)malonate 
• 98-59-9 p-toluenesulfonyl chloride 
• 19515-61-8 diethyl 2-(3-oxo-propyl)malonate 
• 541-41-3 chloroformic acid ethyl ester 
• 90734-81-9 5-(2-cyanoethyl)-2,2-dimethyl-1,3-dioxan-4,6-dione 
• 2417-90-5 bromopropionitrile 
• 996-82-7 sodium diethylmalonate 
• 996-82-7 sodium diethylmalonate 
• 201230-82-2 carbon monoxide 
• 685-87-0 Diethyl 2-bromomalonate 
• 2141-62-0 3-(ethoxy)propionitrile 

Downstream Products

• 87656-82-4 2-(3,5-dimethoxybenzyl)piperidine-3-carboxylic acid 
• 87656-88-0 ((4aR,10aR)-6,8-Dimethoxy-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinolin-1-yl)-phenyl-methanone 
• 87656-80-2 1-(benzyloxycarbonyl)-2-(3,5-dimethoxybenzyl)piperidine-3-carboxylic acid 
• 87656-78-8 2-(3,5-Dimethoxy-benzyl)-piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester 
• 87656-77-7 2-(3,5-Dimethoxy-benzyl)-piperidine-1,3,3-tricarboxylic acid 1-benzyl ester 3-ethyl ester 
• 87656-76-6 diethyl 1-(benzyloxycarbonyl)-2-(3,5-dimethoxybenzyl)piperidine-3,5-dicarboxylate 
• 87657-01-0 trans-6,8-dimethoxy-1-benzyl-1,2,3,4,4a,5,10,10a-octahydrobenzquinoline 
• 87656-74-4 diethyl 2-(3,5-dimethoxybenzyl)piperidine-3,3-dicarboxylate 
• 10444-12-9 diethyl 2-(2-cyanoethyl)-2-ethylmalonate 
• 1356686-13-9 diethyl 2-((1R,4S)-4-(benzylcarbamoyl)cyclobut-2-enyl)-2-(2-cyanoethyl)malonate 
• 3464-81-1 2,3-Dioxo-piperidin-p-tolylhydrazon-⁽³⁾ 
• 110047-11-5 piperidine-2,3-dione-3-(4-methylsulfanyl-phenylhydrazone) 
• 104742-98-5 2,3-dioxopiperidine 3-(p-methoxyphenyl)hydrazone 
• 17952-83-9 6-chloro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one 

Relevant articles and documents

Intramolecular Schmidt reaction of acyl chlorides with alkyl azides: Preparation of pyrrolizine by intramolecular capture of intermediates with alkenes or alkynes

The preparation of substituted pyrrolizines through the Schmidt reaction of acyl chlorides with alkyl azides has been realized. Intramolecular capture of the isocyanate ion and N-acyliminium ion intermediates from the Schmidt process with alkene or alkyne

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DIASTEREOMERIC LINKING REAGENTS FOR NUCLEOTIDE PROBES

A versatile reagent with a non-nucleotide monomeric unit comprising an enantiomeric center and having a ligand, and first and second coupling groups that are linked to the non-nucleotide monomeric unit. Such a reagent permits preparation of versatile nucleotide/non-nucleotide polymers, having any desired sequence of nucleotide and non-nucleotide monomeric units, each of the latter of which bear a desired ligand. These polymers can, for example, be used as probes which can exhibit enhanced sensitivity and/or which are capable of detecting a genus of nucleotides each species of which has a common target nucleotide sequence of interest bridged by different sequences not of interest.

2 - Oxygen -3 - piperidine carboxylic acid ethyl ester preparation method (by machine translation)

The invention provides a 2 - oxo - 3 - piperidine carboxylic acid ethyl ester preparation method, comprising the following steps: S1, the malonic acid diethyl ester and alkaline catalyst after mixing, in the 10 - 50 °C dropping acrylonitrile, obtained by reaction of 2 - cyanoethyl malonic acid diethyl ester; S2, will be the 2 - cyanoethyl malonic acid diethyl ester and organic solvent, [...] catalyst in the hydrogen environment, for 75 - 130 °C react under the, recrystallization to obtain the 2 - oxo - 3 - piperidine carboxylic acid ethyl ester. Compared with the prior art, this invention has the following advantages: the present invention provides a 2 - oxo - 3 - piperidine ethyl formate manufacturing method, with raw materials are easy, simple operation, total yield compared with the classic N·F·Albertsm method up to 77% above (improved 20%), so it is very suitable for industrial production. (by machine translation)