172095-29-3

Basic information

• Product Name: (rac)-(4-isobutyl-5-oxo-2-phenyl-4,5-dihydro-oxazol-4-yl)-acetic acid tert.-butyl ester
• CAS NO: 172095-29-3
• Molecular Weight: 331.412
• Mol File: 172095-29-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (rac)-(4-isobutyl-5-oxo-2-phenyl-4,5-dihydro-oxazol-4-yl)-acetic acid tert.-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (rac)-(4-isobutyl-5-oxo-2-phenyl-4,5-dihydro-oxazol-4-yl)-acetic acid tert.-butyl ester(172095-29-3)
• EPA Substance Registry System: (rac)-(4-isobutyl-5-oxo-2-phenyl-4,5-dihydro-oxazol-4-yl)-acetic acid tert.-butyl ester(172095-29-3)

Safety Data

• Hazardous Substances Data: 172095-29-3(Hazardous Substances Data)

Upstream product

• 1466-83-7 N-benzoyl-DL-leucine 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 25163-98-8 4-isobutyl-2-phenyloxazol-5(4H)-one 
• 107-59-5 tert-Butyl chloroacetate 

Relevant articles and documents

A reinvestigation of the α-alkylation of 4-monosubstituted 2-phenyloxazol-5(4H)-ones ('azlactones'): A general entry into highly functionalized α,α-disubstituted α-amino acids

Novel, more reliable and general reaction conditions for the α-alkylation of 4-monosubstituted 2-phenyloxazol-5(4H)-ones (= 4-monosubstituted 2-phenyl-azlactones) rac-2 to 4,4-disubstituted 2-phenyloxazol-5(4H)-ones rac-1 were found. Thus, a whole range of highly functionalized rac-1 were prepared in medium-to-good overall yields (40-90%). Azlactones rac-1 are ideal precursors for the synthesis of optically pure α,α-disubstituted (R)- and (S)-α-amino acids.