17113-31-4

Basic information

• Product Name: Furan, 2-(p-methoxyphenyl)- (8CI)
• Synonyms: Furan, 2-(p-methoxyphenyl)- (8CI);2-(p-Methoxyphenyl)furan;p-2-Furylanisole
• CAS NO: 17113-31-4
• Molecular Formula: C₁₁H₁₀O₂
• Molecular Weight: 174
• Mol File: 17113-31-4.mol
• Article Data: 99

Chemical Properties

• Melting Point: 54-55℃
• Appearance: /
• CAS DataBase Reference: Furan, 2-(p-methoxyphenyl)- (8CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Furan, 2-(p-methoxyphenyl)- (8CI)(17113-31-4)
• EPA Substance Registry System: Furan, 2-(p-methoxyphenyl)- (8CI)(17113-31-4)

Safety Data

• Hazardous Substances Data: 17113-31-4(Hazardous Substances Data)

Usage

Description

Furan, 2-(p-methoxyphenyl)(8CI), also known as 2-(4-methoxyphenyl)furan, is a chemical compound with the molecular formula C11H10O2. It is a derivative of furan, a heterocyclic compound characterized by a five-membered ring structure with four carbon atoms and one oxygen atom. This specific derivative features a p-methoxyphenyl group attached to the furan ring, which endows it with unique chemical and biological properties. It is widely recognized as a versatile building block in the synthesis of various pharmaceuticals and organic compounds, and is also valued for its potential biological activities, such as anti-inflammatory and analgesic properties. Furthermore, it serves as a starting material in research for the development of new drugs and chemical substances.

Uses

Used in Pharmaceutical Industry:
Furan, 2-(p-methoxyphenyl)(8CI) is used as a building block for the synthesis of various pharmaceuticals and organic compounds. Its unique structure and properties make it a valuable component in the creation of new drugs and chemical substances, contributing to the advancement of medicinal chemistry.
Used in Research and Development:
Furan, 2-(p-methoxyphenyl)(8CI) is used as a starting material in research for the development of new drugs and chemical substances. Its potential biological activities, including anti-inflammatory and analgesic properties, make it a promising candidate for further exploration and application in the field of drug discovery.
Used in Organic Synthesis:
Furan, 2-(p-methoxyphenyl)(8CI) is used as a key intermediate in organic synthesis, particularly in the preparation of complex organic molecules and compounds. Its reactivity and structural features facilitate the formation of diverse chemical entities, expanding the scope of synthetic chemistry.

Upstream product

• 110-00-9 furan 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 775-27-9 4-methoxyphenyl sulfurofluoridate 
• 102732-72-9 <5-(4-Methoxyphenyl)-2-furylmethyl>-methyl-(1-methyl-2-phenyl-ethyl)-amin 
• 67-56-1 methanol 
• 16469-68-4 1-(4-methoxyphenyl)-2-propyn-1-one 
• 104-94-9 4-methoxy-aniline 
• 696-62-8 para-iodoanisole 
• 118486-94-5 2-(tributylstannyl)furan 
• 196952-70-2 1-(4-methoxyphenyl)buta-2,3-dien-1-one 
• 5720-07-0 4-methoxyphenylboronic acid 
• 18649-43-9 4-methoxyphenyllead(IV) triacetate 
• 733-53-9 p-methoxyphenyl(phenyl)iodonium tetrafluoroborate 
• 4456-36-4 di(p-methoxyphenyl)tellurium dichloride 

Downstream Products

• 151427-00-8 2-(4-methoxyphenyl)-5-(4-pyridyl)furan 
• 87689-40-5 [5-(4-Methoxy-phenyl)-furan-2-ylmethyl]-dimethyl-amine; hydrochloride 
• 84185-78-4 (E)-2-[5-(4-Methoxy-phenyl)-furan-2-yl]-but-2-enedioic acid 
• 84185-72-8 3-(p-anisyl)-6-hydroxyphthalic anhydride 
• 1230-48-4 2,5-Bis(4-methoxyphenyl)furan 
• 126739-60-4 2-(4′-methoxyphenyl)-5-(4′-nitrophenyl)furan 
• 72310-69-1 2-(5-<4-methoxy>phenyl-2-furyl)ethanol 
• 17113-34-7 dimethyl 3-hydroxy-6-(4-methoxyphenyl)phthalate 
• 20842-13-1 1-(4-Methoxy-phenyl)-7-oxa-bicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylic acid dimethyl ester 
• 214463-16-8 N-(2-(5-<4-methoxy>phenyl-2-furyl)ethyl)-2,5-pyrrolidinedione 
• 214463-20-4 N-(2-(5-<4-methoxy>phenyl-2-furyl)ethyl)-5-hydroxy-2-pyrrolidinone 
• 214463-17-9 N-(2-(5-<4-methoxy>phenyl-2-furyl)ethyl)-2,6-piperidinedione 
• 214463-23-7 N-(2-(5-<4-methoxy>phenyl-2-furyl)ethyl)-6-hydroxy-2-piperidinone 

Relevant articles and documents

Efficient procedure for the preparation of 2-bromofuran and its application in the synthesis of 2-arylfurans

A simple, straightforward, and scalable procedure for the preparation of 2-bromofuran using N-bromosuccinimide (NBS) in dimethylformamide (DMF) is reported. The described preparation is conducted on a 20 to 50g scale and does not require extractive workup procedures or chromatographic purifications. To illustrate the synthetic applications of 2-bromofuran, palladium-catalyzed Suzuki coupling reactions of the prepared 2-bromofuran with various aryl boronic acids were investigated, and moderate to good yields of 2-arylfurans were obtained. Copyright Taylor & Francis Group, LLC.

New Nickel-Based Catalytic System with Pincer Pyrrole-Functionalized N-Heterocyclic Carbene as Ligand for Suzuki-Miyaura Cross-Coupling Reactions

A new catalytic system with Ni(NO3)2·6H2O as the catalyst and a pincer pyrrole-functionalized N-heterocyclic carbene as the ligand was employed in the Suzuki-Miyaura cross-coupling reactions of aryl iodides with arylboronic acids. With 5 mol% catalyst, the catalytic reactions proceeded at 160 °C, giving coupling products in isolated yields of up to 94% in short reaction times (1-4 h). The system worked efficiently with aryl iodides bearing electron-donating or electron-withdrawing groups and arylboronic acids with electron-donating groups. Steric effects were observed for both aryl iodides and arylboronic acids. It is proposed that the reactions underwent a Ni(I)/Ni(III) catalytic cycle.

Pd-NHCs Enabled Suzuki-Miyaura Cross-Coupling of Arylhydrazines via C–N Bond Cleavage

We describe a highly efficient protocol for cross-coupling of phenylhydrazines with arylboronic acids by Pd-NHCs under aerobic reaction condition. A series of well-defined Pd-NHCs complexes were evaluated and the relationship between the structure and the catalytic properties was investigated. It was disclosed that the Pd-PEPPSI-IPr proved to be the robust precatalyst, providing access to a range of (hetero)biaryls in good to excellent yields.

Pyrazole-Mediated C-H Functionalization of Arene and Heteroarenes for Aryl-(Hetero)aryl Cross-Coupling Reactions

Herein we introduce a transition-metal-free protocol that involves a commercially available, inexpensive pyrazole molecule to conduct C-C cross-coupling reactions at room temperature via a radical pathway. Using this method, an aryldiazonium salt has been coupled to a wide range of arenes and heteroarenes including benzene, mesitylene, thiophene, furan, benzoxazole to result the corresponding biaryl products. The full reaction mechanism is elucidated along with the crystallographic probation of an active initiator species. A potassium-stabilized deprotonated pyrazole steers single-electron transfer to the substrate and behaves as an initiator for the reaction.