170701-87-8

Basic information

• Product Name: AZIRIDINE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER 2-METHYL ESTER
• Synonyms: AZIRIDINE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER 2-METHYL ESTER
• CAS NO: 170701-87-8
• Molecular Formula: C₁₂H₁₃NO₄
• Molecular Weight: 235.24
• Product Categories: pharmacetical
• Mol File: 170701-87-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 160-165 °C2 mm Hg(lit.)
• Appearance: /
• Density: 1.19 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.519(lit.)
• Storage Temp.: 2-8°C
• PKA: -5.65±0.40(Predicted)
• CAS DataBase Reference: AZIRIDINE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER 2-METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: AZIRIDINE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER 2-METHYL ESTER(170701-87-8)
• EPA Substance Registry System: AZIRIDINE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER 2-METHYL ESTER(170701-87-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 170701-87-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
Aziridine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester is used as a research compound for exploring its potential biological activities and therapeutic properties. Its unique structure and properties make it a promising candidate for the development of new drugs and pharmaceutical agents.
Used in Drug Development:
Aziridine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester is used as a building block or intermediate in the synthesis of novel compounds with potential therapeutic applications. Its chemical properties and reactivity can be exploited to create new molecules with desired pharmacological effects, contributing to the advancement of drug discovery and development.
Used in Synthesis of Bioactive Compounds:
Aziridine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester is used as a key component in the synthesis of bioactive compounds with potential applications in various therapeutic areas. Its unique functional groups and reactivity can be utilized to create new molecules with specific biological activities, such as antimicrobial, antiviral, or anticancer properties.
Further research is needed to fully understand the potential uses and effects of this chemical compound, as well as to optimize its synthesis and application in various fields.

Upstream product

• 14464-15-4 methyl 2-(benzyloxycarbonylamino)-3-hydroxypropanoate 
• 5950-34-5 methyl aziridine-2-carboxylate 
• 501-53-1 benzyl chloroformate 
• 76357-18-1 methyl 1-tritylaziridine-2-carboxylate 
• 91174-01-5 sodium [(benzyloxy)carbonyl]chloroamide 
• 292638-85-8 acrylic acid methyl ester 

Downstream Products

• 5950-34-5 methyl aziridine-2-carboxylate 
• 1268474-82-3 (R)-2-(benzyloxycarbonylamino)-3-(1-chloropropan-2-yloxy)propanoic acid 
• 1268474-80-1 (R)-methyl 2-(benzyloxycarbonylamino)-3-(1-chloropropan-2-yloxy)propanoate 
• 913979-63-2 C₂₂H₃₁N₃O₆ 
• 16112-59-7 4-methyl-2-oxazolidone 
• 64356-78-1 2-Benzyloxycarbonylamino-3-methylsulfanyl-propionic acid methyl ester 

Relevant articles and documents

PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF DIABETES OR OBESITY COMPRISING A COMPOUND THAT INHIBITS ACTIVITY OF DIPEPTIDYL PEPTIDASE-IV, AND OTHER ANTIDIABETIC OR ANTIOBESITY AGENTS AS ACTIVE INGREDIENTS

The present invention relates to a pharmaceutical composition for the prevention and treatment of diabetes or obesity comprising as active ingredients a compound which inhibits the activity of dipeptidyl peptidase-IV(DPP-IV), a pharmaceutically acceptable

Efficient Synthesis of N-Sulfonyl β -Arylmethylalaninates from Serine via Ring Opening of N-Sulfonyl Aziridine-2-carboxylate

We report the efficient synthesis of N-sulfonyl β-arylalanines methyl ester through regioselective ring opening of N-protected aziridines by variety of heteroaryl C-nucleophiles. We have optimized synthesis of N-protected aziridines with versatile protecting groups to afford 4a-c, 6a, and 6b with moderate to good yields using sulfuryl chloride, triethyl amine, and toluene at -50 °C. The present work reports on the studies related to electronic effect of nitrogen substituent on aziridination from the inexpensive starting material DL-serine. The present investigation also reports the efficient synthesis of N-sulfonyl β-arylmethylalaninates (7a-e and 8a-e) by regioselective nucleophilic ring opening of N-sulfonamido-protected aziridines using various aryl moieties such as C-nucleophiles and Lewis acids (InCl3, FeCl3, Cu(OTf)2) as catalysts and some trials by ring opening using Grignard reagent. GRAPHICAL ABSTRACT.

Efficient regioselective ring opening of activated aziridine-2-carboxylates with [18F]fluoride

Aziridines can undergo a range of ring-opening reactions with nucleophiles. The regio- and stereochemistry of the products depend on the substituents on the aziridine. Aziridine ring-opening reactions have rarely been used in radiosynthesis. Herein we rep

Catalytic aziridination of electron-deficient olefins with an N-chloro-N-sodio carbamate and application of this novel method to asymmetric synthesis

A new method for the aziridination of electron-deficient olefins using an N-chloro-N-sodio carbamate is described; the reaction was promoted by phase-transfer catalysis (solid-liquid) and afforded aziridines from α,β-unsaturated ketones, esters, sulfones and amides. The Royal Society of Chemistry 2008.

L-aminodicarboxylic-(O-cycloalkyl)-L-aminocarboxylate alkyl ester sweeteners

Dipeptides of certain α-amino dicarboxylic acids and etherified hydroxy α-amino-mono-carboxylic acid esters possess a high order of sweetness. These dipeptides have the following formula: STR1 wherein R is alkyl containing 1-3 carbon atoms; R1

L-aminodicarboxylic acid amides of alkoxyalkylamines

The present invention is directed to new sweeteners of the formula: STR1 wherein, A is H, alkyl containing 1-3 carbon atoms, hydroxyalkyl containing 1-3 carbon atoms, alkoxymethyl wherein the alkoxy group contains 1-3 carbon atoms, or CO2 R in

L-aminodicarboxylic acid amides

Amides of α-aminodicarboxylic acids and β-aminoethers are low calorie sweetners.