17061-62-0

Basic information

• Product Name: BIS-(4-METHOXY-BENZYL)-AMINE
• Synonyms: CHEMBRDG-BB 5550428;BIS-(4-METHOXY-BENZYL)-AMINE;N,N-bis(4-methoxybenzyl)amine;BenzeneMethanaMine, 4-Methoxy-N-[(4-Methoxyphenyl)Methyl]-;Bis(4-methoxybenzyl)
• CAS NO: 17061-62-0
• Molecular Formula: C₁₆H₁₉NO₂
• Molecular Weight: 257.33
• EINECS: 200-258-5
• Mol File: 17061-62-0.mol
• Article Data: 80

Chemical Properties

• Melting Point: 35-37℃
• Boiling Point: 384℃
• Flash Point: 161℃
• Appearance: /
• Density: 1.073
• Storage Temp.: 2-8°C(protect from light)
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 9.55±0.20(Predicted)
• CAS DataBase Reference: BIS-(4-METHOXY-BENZYL)-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: BIS-(4-METHOXY-BENZYL)-AMINE(17061-62-0)
• EPA Substance Registry System: BIS-(4-METHOXY-BENZYL)-AMINE(17061-62-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 17061-62-0(Hazardous Substances Data)

Usage

Description

BIS-(4-METHOXY-BENZYL)-AMINE, also known as N,N-Bis(4-methoxybenzyl)amine, is an organic compound that serves as a crucial reagent in the synthesis of various pharmaceutical agents. It is characterized by its ability to form essential intermediates in the development of drugs targeting specific enzymes and viruses.

Uses

Used in Pharmaceutical Synthesis:
BIS-(4-METHOXY-BENZYL)-AMINE is used as a reagent for the synthesis of pentanedioc acid derivatives, which are farnesyltransferase inhibitors. These inhibitors play a significant role in the development of drugs targeting enzymes involved in various diseases.
Used in Antiviral Drug Development:
In the field of antiviral research, BIS-(4-METHOXY-BENZYL)-AMINE is utilized in the preparation of (heteroarylamino)triazolamines. These compounds exhibit antiviral properties, making them useful in the treatment of Hepatitis C virus (HCV) infection, offering potential therapeutic solutions for patients suffering from this viral disease.

InChI:InChI=1S/C16H19NO2/c1-18-15-7-3-13(4-8-15)11-17-12-14-5-9-16(19-2)10-6-14/h3-10,17H,11-12H2,1-2H3

Upstream product

• 108-94-1 cyclohexanone 
• 874-90-8 4-methoxybenzonitrile 
• 64-17-5 ethanol 
• 123-11-5 4-methoxy-benzaldehyde 
• 141-78-6 ethyl acetate 
• 3717-21-3 (E)-4-methoxybenzaldoxime 
• 64-19-7 acetic acid 
• 3261-60-7 N-(4-methoxybenzylidene)-4-methoxybenzylamine 
• 2393-23-9 4-methoxy-benzylamine 
• 100-52-7 benzaldehyde 
• 1077-18-5 N-benzylidenebutan-1-amine 
• 3424-93-9 4-methoxyphenylacetamide 
• 105-13-5 4-Methoxybenzyl alcohol 
• 3717-21-3 p-methoxyl benzaldoxime 

Downstream Products

• 1224113-91-0 N,N-bis(4-methoxybenzyl)-N'-(4-tolyl)selenourea 
• 863296-87-1 4-(bromomethyl)-N,N-bis(4-methoxybenzyl)benzenesulfonamide 
• 50918-77-9 methyl (N,N-di-p-methoxybenzyl)carbamoyloxyacetate 
• 884004-38-0 6-chloro-N,N-bis[(4-methoxyphenyl)methyl]-5-(trifluoromethyl)pyridin-2-amine 
• 903578-45-0 5-iodo-2-[methanesulfonyl-(4-methoxy-benzyl)-amino]-N,N-bis-(4-methoxy-benzyl)-benzamide 
• 903578-46-1 4-bromo-2-fluoro-N,N-bis[(4-methoxyphenyl)methyl]benzenesulfonamide 
• 811794-13-5 2-(1,3-dioxoisoindolin-2-yl)-N,N-bis(4-methoxybenzyl)ethanesulfonamide 
• 634927-84-7 {2-[2-(2-[bis{4-methoxybenzyl}amino]-6-chloro-5-methyl-3-nitropyridin-4-ylamino)ethoxy]ethyl}carbamic acid tert-butyl ester 
• 133778-03-7 Benzoic acid 4-(3-[bis-(4-methoxy-benzyl)-sulfamoyl]-1-{2-[bis-(4-methoxy-benzyl)-sulfamoyl]-ethyl}-1-methoxycarbonyl-propyl)-phenyl ester 
• 133778-02-6 4-[Bis-(4-methoxy-benzyl)-sulfamoyl]-2-{2-[bis-(4-methoxy-benzyl)-sulfamoyl]-ethyl}-2-(4-bromo-phenyl)-butyric acid methyl ester 
• 133778-01-5 4-[Bis-(4-methoxy-benzyl)-sulfamoyl]-2-{2-[bis-(4-methoxy-benzyl)-sulfamoyl]-ethyl}-2-phenyl-butyric acid methyl ester 
• 133778-24-2 methyl α-<2-<amino>-sulfonyl>ethyl>-4-<2-(1,1-dimethylethoxy)-2-oxoethoxy>benzeneacetate 
• 133777-99-8 methyl 4-(benzoyloxy)-α-<2-<amino>sulfonyl>ethyl>benzeneacetate 
• 133777-98-7 methyl α-<2-<amino>sulfonyl>ethyl>-4-bromobenzeneacetate 

Relevant articles and documents

Synthesis, spectral, crystal structures, Hirshfeld surface analysis and DFT studies on bis(N,N-di(4-methoxybenzyl)dithiocarbamato-S,S′)zinc(II) and its imine adducts: new precursor for the preparation of hexagonal ZnS

[Zn(4-mbzdtc)2] (1), [Zn(4-mbzdtc)2(py)] (2), [Zn2(4-mbzdtc)4(4,4′-bipy)] (3), and [Zn(4-mbzdtc)2(2,2′-bipy)] (4), (where, 4-mbzdtc = N,N-di(4-methoxybenzyl)dithiocarbamate) were prepared and characte

Photo-Electroswitchable Arylaminoazobenzenes

Azobenzenes appended with a redox-active arylamino group (redox auxiliary, RA) are prepared and shown to undergo fast, complete, and catalytic Z→E azo isomerization upon electron loss from the RA unit of the azobenzene. The RA-azo structures can be reversibly (E→Z→E)n cycled by sequential photo- and electrostimulation. Due to the robust nature of the RA?+-azo radical cation chain carrying species, initiation of electron transfer (ET) catalysis occurs at low levels (1.0-0.04 mol %) of catalytic loading and is effective even at Z-RA-azo concentrations of 10-4-10-5 M, yielding TONs (turnover numbers) of 100-2300 under such dilute conditions. The RA-azo Z→E conversion is demonstrated using chemical oxidation (redox switching), electrochemical oxidation (electro switching), and photochemical oxidation (photoredox switching). The Z→E acceleration is shown to be at least 2 × 109-fold for RA-azo 5. DFT calculations on methyl yellow suggest that a N-centered radical cation of the RA group stabilizes the Z→E N-N twist transition state of the RA?+-azo, yielding a large reduction in the barrier for RA?+-azo compared to neutral RA-azo. The RA-azo structure class has nanomechanical features that can be toggled with photo- and electrostimulation, the latter offering a quick switch for complete Z→E conversion.

Platinum Nanoparticles Uniformly Dispersed on Covalent Organic Framework Supports for Selective Synthesis of Secondary Amines

Covalent organic frameworks (COFs) with pore structures are talented supports for active components. In this report, COF has been rationally fabricated and served as host for growing uniformly dispersed platinum nanoparticles with a narrow size distribution (2 nm). The obtained hybrid Pt/COF exhibits high catalytic activity in the reductive amination of benzaldehyde towards secondary amines with a yield of 96 % and good recyclability. The preferable selectivity towards secondary amines could be attributed to synergistic effects of active platinum nanoparticles and COF, in which metallic Pt nanoparticles were uniformly dispersed with a positively charged surface. This work will open an avenue towards controlling the interaction between active metals and support as well as rational design of catalysts for demanding transformations for fine agrochemicals intermediates.