1706-12-3

Basic information

• Product Name: 1-METHYL-4-PHENOXY-BENZENE
• Synonyms: 1-METHYL-4-PHENOXY-BENZENE;p-phenoxytoluene;4-Methyldiphenyl ether;4-Methylphenylphenyl ether;Phenyl 4-methylphenyl ether;Phenyl p-tolyl ether;Phenyl(4-methylphenyl) ether
• CAS NO: 1706-12-3
• Molecular Formula: C₁₃H₁₂O
• Molecular Weight: 184.23378
• EINECS: 216-944-3
• Mol File: 1706-12-3.mol
• Article Data: 164

Chemical Properties

• Melting Point: 104 °C
• Boiling Point: 268.8°Cat760mmHg
• Flash Point: 110.6°C
• Appearance: /
• Density: 1.045g/cm³
• Vapor Pressure: 0.0125mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-METHYL-4-PHENOXY-BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-4-PHENOXY-BENZENE(1706-12-3)
• EPA Substance Registry System: 1-METHYL-4-PHENOXY-BENZENE(1706-12-3)

Safety Data

• Hazardous Substances Data: 1706-12-3(Hazardous Substances Data)

Usage

General Description

1-METHYL-4-PHENOXY-BENZENE, also known as PMPOB, is a chemical compound with the molecular formula C13H12O. It is a colorless to light yellow liquid that is insoluble in water but soluble in organic solvents. PMPOB is primarily used as an intermediate in the synthesis of pharmaceuticals, dyes, and other organic compounds. It is also used in research and development as a building block for organic synthesis. The compound is known to have low acute toxicity and is not considered to be a significant environmental or health hazard when handled and used according to proper safety guidelines.

InChI:InChI=1/C13H12O/c1-11-7-9-13(10-8-11)14-12-5-3-2-4-6-12/h2-10H,1H3

Upstream product

• 108-86-1 bromobenzene 
• 106-44-5 p-cresol 
• 1192-96-7 potassium p-cresolate 
• 41295-20-9 4-(4-methylphenoxy)aniline 
• 108-95-2 phenol 
• 1121-70-6 sodium 4-methylphenoxide 
• 624-31-7 4-tolyl iodide 
• 139-02-6 sodium phenoxide 
• 106-38-7 para-bromotoluene 
• 108-98-5 thiophenol 
• 108-90-7 chlorobenzene 
• 66694-17-5 (E)-2-phenyl-1-phenoxyethene 
• 262373-15-9 4-methyl-2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 591-50-4 iodobenzene 

Downstream Products

• 36881-42-2 1-(bromomethyl)-4-phenoxybenzene 
• 6103-33-9 2-methylphenoxathiin 
• 2215-77-2 4-Phenoxybenzoic acid 
• 30427-93-1 1-bromo-4-(4-methylphenoxy)benzene 
• 71815-31-1 4-(p-tolyloxy)acetophenone 
• 192329-90-1 4-p-tolyloxy-benzenesulfonyl chloride 
• 3991-61-5 1-methyl-2-phenoxybenzene 
• 106-44-5 p-cresol 
• 108-88-3 toluene 
• 71-43-2 benzene 
• 108-95-2 phenol 
• 7320-51-6 2-methyldibenzofuran 
• 54104-82-4 1-p-tolylpyrrolidine 
• 745028-41-5 C₁₁H₁₇N 

Relevant articles and documents

Oxidation of m-Phenoxytoluene with Ceric Trifluoroacetate

Ceric trifluoroacetate in aqueous trifluoroacetic acid has been found to be especially effective for the oxidation of activated toluenes to the corresponding aldehydes.Ceric ion is consumed in stoichiometric amounts but can be regenerated electrochemically at high current efficiencies (95 percent).A detailed study of the oxidation of m-phenoxytoluene to m-phenoxybenzaldehyde is presented.A study of the reaction mechanism, which involves both cations and radical cations, led to a choise of cosolvents which stabilize these intermediates and thus increase the yield of aldehyde formation.

Ligand- and Counterion-Assisted Phenol O-Arylation with TMP-Iodonium(III) Acetates

High reactivity of trimethoxyphenyl (TMP)-iodonium(III) acetate for phenol O-arylation was achieved. It was first determined that the TMP ligand and acetate anion cooperatively enhance the electrophilic reactivity toward phenol oxygen atoms. The proposed method provides access to various diaryl ethers in significantly higher yields than the previously reported techniques. Various functional groups, including aliphatic alcohol, boronic ester, and sterically hindered groups, were tolerated during O-arylation, verifying the applicability of this ligand- and counterion-assisted strategy.

Copper nanoparticle anchored biguanidine-modified Zr-UiO-66 MOFs: a competent heterogeneous and reusable nanocatalyst in Buchwald-Hartwig and Ullmann type coupling reactions

We have designed a functionalized metal-organic framework (MOF) of UiO topology as a support, with an extremely high surface area, adjustable pore sizes and stable crystalline coordination polymeric structure and implanted copper (Cu) nanoparticles thereon. The core three dimensional Zr-derived MOF (UiO-66-NH2) was modified with a biguanidine moiety following a covalent post-functionalization approach. The morphological and physicochemical features of the material were determined using analytical methods such as FT-IR, SEM, TEM, EDX, atomic mapping, XRD and ICP-OES. The SEM and XRD results justified the unaffected morphology of Zr-MOF after structural modifications. The as-synthesized UiO-66-biguanidine/Cu nanocomposite was catalytically explored in the aryl and heteroaryl Buchwald-Hartwig C-N and Ullmann type C-O cross coupling reactions with excellent yields. A library of biaryl amine and biaryl ethers was synthesized over the catalyst under mild and green conditions. Furthermore, the catalyst was isolated by centrifugation and recycled 11 times with no significant copper leaching or change in its activity.