170210-50-1 Usage
Description
(2S-CIS)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLANE-4-METHANOL, METHANESULFONATE (ESTER)KETOCONAZOLE is a synthetic chemical compound that serves as the active ingredient in the antifungal medication ketoconazole. It is characterized by its ability to inhibit fungal growth and disrupt the production of ergosterol, a vital component of fungal cell membranes.
Used in Pharmaceutical Industry:
(2S-CIS)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLANE-4-METHANOL, METHANESULFONATE (ESTER)KETOCONAZOLE is used as an antifungal agent for the treatment of various fungal infections, including histoplasmosis, blastomycosis, and cryptococcosis, as well as infections caused by certain types of yeasts. Its mechanism of action involves inhibiting fungal growth and disrupting the production of ergosterol, which is essential for the integrity of fungal cell membranes.
Check Digit Verification of cas no
The CAS Registry Mumber 170210-50-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,0,2,1 and 0 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 170210-50:
(8*1)+(7*7)+(6*0)+(5*2)+(4*1)+(3*0)+(2*5)+(1*0)=81
81 % 10 = 1
So 170210-50-1 is a valid CAS Registry Number.
170210-50-1Relevant articles and documents
Stereoselective Syntheses of Both Enantiomers of Ketoconazole from (R)- and (S)-Epichlorohydrin
Camps, Pelayo,Farres, Xavier,Garcia, Luisa,Ginesta, Joan,Pascual, Jaume,et al.
, p. 1283 - 1294 (2007/10/03)
Stereoselective syntheses of both enantiomers of ketoconazole (1) from commercially available (R)- or (S)-epichlorohydrin has been developed.The key-step of syntheses involves the selective substitution of the methylene chlorine atom by benzoate on a mixture of (2S,4R)-14a and (2R,4R)-15a or of their enentiomers, followed by crystalization of the corresponding cis-benzoates, (2R,4R)-18 or (2S,4S)-18, from which (+)- or (-)-1 were obtained as described for (+/-)-1.The ee's of (+)- and (-)-ketocanazole were determined by HPLC on the CSP Chiracel OD-H.
