1701-95-7

Basic information

• Product Name: Benzoic acid, 2-(1,4-dihydro-2,4-dioxo-3(2H)-quinazolinyl)-
• CAS NO: 1701-95-7
• Molecular Formula: C15H10N2O4
• Molecular Weight: 282.255
• Mol File: 1701-95-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-(1,4-dihydro-2,4-dioxo-3(2H)-quinazolinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-(1,4-dihydro-2,4-dioxo-3(2H)-quinazolinyl)-(1701-95-7)
• EPA Substance Registry System: Benzoic acid, 2-(1,4-dihydro-2,4-dioxo-3(2H)-quinazolinyl)-(1701-95-7)

Safety Data

• Hazardous Substances Data: 1701-95-7(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 5100-23-2 2-isocyanatobenzoyl chloride 
• 102081-79-8 diethyl 2,2'-[carbonylbis(azanediyl)]dibenzoate 
• 79860-05-2 2-dimethylammonio-(4H)-3,1-benzoxazine-4-one chloride 
• 118-92-3 anthranilic acid 
• 118-48-9 isatoic anhydride 
• 79860-15-4 2-[2-(3,3-Dimethyl-ureido)-benzoylamino]-benzoic acid 

Downstream Products

• 25380-15-8 2-(4-oxo-4H-quinazolin-3-yl)benzoic acid 

Relevant articles and documents

Radical reactions with 3H-quinazolin-4-ones: Synthesis of deoxyvasicinone, mackinazolinone, luotonin A, rutaecarpine and tryptanthrin

Alkyl, aryl, heteroaryl and acyl radicals have been cyclised onto the 2-position of 3H-quinazolin-4-one. The side chains containing the radical precursors were attached to the nitrogen atom in the 3-position. The cyclisations take place by aromatic homolytic substitution hence retain the aromaticity of the 3H-quinazolin-4-one ring. The highest yields were obtained using hexamethylditin to facilitate cyclisation rather than reduction without cyclisation. The alkaloids deoxyvasicinone 2, mackinazolinone 3, tryptanthrin 4, luotonin A 5 and rutaecarpine 8 were synthesised by radical cyclisation onto 3H-quinazolin-4-one. This journal is The Royal Society of Chemistry.

HETEROCYCLIZATION WITH IMINIUM CHLORIDES, II. SYNTHESIS OF 4H--BENZOXAZINE-4-ONES AND QUINAZOLINONES

Reactions between methyl anthranilate and a variety of PI salts afforded 2-ammonio-4H--benzoxazine-4-one chlorides which were subjected to nucleophilic reactions.With primary amines, 2-ureidoanthraniloyl amides were obtained, which were smoothly cyclized in boiling acetic anhydride or dimethylformamide to give 1H,3H-quinazoline-2,4-diones.