1694-92-4Relevant articles and documents
MYELINATION STIMULATOR COMPOUNDS, AND METHODS OF TREATMENT
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Page/Page column 27, (2019/11/28)
The invention is directed towards compounds, methods of stimulating myelination, stimulating proliferation of oligodendrocytes (OLs) or stimulating oligodendrocyte precursor cells and methods of treating diseases, disorders or symptoms thereof.
Pharmaceutical intermediates in the synthesis of ortho-nitrophenyl-sulfonyl chloride (by machine translation)
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Paragraph 0013; 0016-0027, (2018/07/30)
This invention relates to pharmaceutical intermediates in the synthesis of ortho-nitrophenyl-sulfonyl chloride method, comprises the following steps: in the reaction container by adding 5 - hydroxy - 6 - methyl nitrobenzene - sulfur, potassium chloride solution, raising the temperature of the solution, the reaction, then batches and join the trichloro acetic acid solution, the stirring speed is; in time in three batches and adding lauryl carbonyl iron, in raised in temperature, to continue to reaction, the temperature is lowered, separating solid, filtering, for sodium sulfate solution many times, triethylamine solution many times, nonane solution many times, in the alcohol solution to recrystallize, desiccant dehydration, to get finished ortho-nitrophenyl-sulfonyl chloride. (by machine translation)
2-Nitrobenzenesulfonyl chloride and synthetic method and application thereof
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Paragraph 0006; 0021; 0022, (2017/08/30)
The invention discloses 2-nitrobenzenesulfonyl chloride and a synthetic method and application thereof; the synthetic method comprises the steps of (a) subjecting 2-nitrochlorobenzene and sodium thiomethoxide to etherification, filtering, recrystallizing the obtained filter cake, centrifugally separating, and drying to obtain dried 2-nitrophenyl sulfur ether; (b) chlorinating the dried 2-nitrophenyl sulfur ether to obtain a wet crude product; refining, and drying to obtain the finished 2-nitrobenzenesulfonyl chloride. By modifying the prior art, it is possible to eliminate the intermediate product, disulfides, with the turbidity of the product fully controlled to 2 and below, and the requirement of liquid crystal materials for the turbidity is met; compared with the prior art, the 2-nitrobenzenesulfonyl chloride and the synthetic method and application thereof have the advantages that the process cost is low and the more applications of 2-nitrobenzenesulfonyl chloride are available in the field of liquid crystal materials and other fields.