16937-99-8

Basic information

• Product Name: BOC-D-Leucine monohydrate
• Synonyms: N-(TERT-BUTOXYCARBONYL)-D-LEUCINE;N-ALPHA-T-BOC-D-LEUCINE;BOC-D-LEU-OH;BOC-D-LEUCINE;L-LEUCINE-5,5,5-D3, N-T-BOC DERIV.H20 98;N-T-BOC-D-LEUCINE;N-TERT-BUTOXYCARBONYL-D-LEUCINE 1-HYDRATE;Boc-D-Leu-OH hydrate
• CAS NO: 16937-99-8
• Molecular Formula: C₁₁H₂₁NO₄
• Molecular Weight: 249.3
• EINECS: 1312995-182-4
• Product Categories: Amino Acids;Leucine [Leu, L];Boc-Amino Acids and Derivative;Amino Acids (N-Protected);Biochemistry;Boc-Amino Acids;Boc-Amino acid series
• Mol File: 16937-99-8.mol
• Article Data: 19

Chemical Properties

• Melting Point: 85-87 °C(lit.)
• Boiling Point: 356 °C at 760 mmHg
• Flash Point: 169.1 °C
• Appearance: white fine crystals
• Density: 1.061 g/cm3
• Vapor Pressure: 4.98E-06mmHg at 25°C
• Refractive Index: 25 ° (C=2, AcOH)
• Storage Temp.: −20°C
• Solubility: Acetic Acid (Sparingly), DMSO (Slightly), Methanol (Slightly)
• PKA: 4.02±0.21(Predicted)
• BRN: 2331060
• CAS DataBase Reference: BOC-D-Leucine monohydrate(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-D-Leucine monohydrate(16937-99-8)
• EPA Substance Registry System: BOC-D-Leucine monohydrate(16937-99-8)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 16937-99-8(Hazardous Substances Data)

Usage

Description

BOC-D-Leucine monohydrate is an N-Boc-protected form of D-Leucine, an unnatural isomer of L-Leucine. It is a white crystalline substance that acts as an auto-inhibitor of lactic streptococci in culture and has potential applications in various industries.

Uses

Used in Pharmaceutical Industry:
BOC-D-Leucine monohydrate is used as an analgesic agent for its ability to cause analgesia in humans. It is also used as an inhibitor in bacterial cell cultures due to its inhibitory activity.
Used in Chemical Synthesis:
BOC-D-Leucine monohydrate is used as a protected amino acid in the synthesis of peptides and other organic compounds, where the N-Boc group can be selectively removed to reveal the free D-Leucine.
Used in Research and Development:
BOC-D-Leucine monohydrate is used as a research compound for studying the properties and applications of D-Leucine and its derivatives, as well as for investigating the mechanisms of auto-inhibition in lactic streptococci.

InChI:InChI=1/C11H21NO4.H2O/c1-7(2)6-8(9(13)14)12-10(15)16-11(3,4)5;/h7-8H,6H2,1-5H3,(H,12,15)(H,13,14);1H2/t8-;/m1./s1

Upstream product

• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 328-38-1 (R)-leucine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 129568-83-8 (2R,2'R)-N-(2'-amino-4'-methylpentanoyl)bornane-10,2-sultam 
• 19792-08-6 p-nitrophenyl-N-(t-butoxycarbonyl)-D-leucinate 
• 41840-28-2 S-tert-butoxycarbonyl-4,6-dimethyl-2-mercaptopyrimidine 
• 170642-24-7 (R)-2-Amino-4-methyl-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide 
• 54594-06-8 D-allylglycine 
• 73371-96-7 2-<<(tert-butoxycarbonyl)oxy>imino>-2-phenylacetonitrile 
• 38136-29-7 4-methylvaleroyl chloride 
• 129505-08-4 (2R,2'R)-N-<2'-(hydroxyamino)-4'-methylpentanoyl>bornane-10,2-sultam 
• 129505-02-8 (2R)-N-(4-methylpentanoyl)bornane-10,2-sultam 
• 170642-23-6 (S,S)-pseudoephedrine D-allylglycinamide 
• 219819-68-8 tert-butyl (R)-2-(((tert-butyldimethylsilyl)oxy)-methyl)aziridine-1-carboxylate 

Downstream Products

• 60654-42-4 Boc-D-Leu-NH-NH-Z 
• 78834-53-4 BOC-D-Leu-L-Val-pNA 
• 140834-91-9 Boc-D-Leu-Phe-OBzl 
• 137022-74-3 Boc-D-Leu-Gly-NHOBzl 
• 137029-92-6 [(R)-1-((S)-1-Benzyl-2-oxo-2-piperidin-1-yl-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid tert-butyl ester 
• 137005-62-0 {(R)-1-[(S)-1-Benzyl-2-oxo-2-(4-phenyl-piperidin-1-yl)-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid tert-butyl ester 
• 137005-63-1 {(R)-1-[(S)-1-Benzyl-2-oxo-2-(4-phenyl-piperazin-1-yl)-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid tert-butyl ester 
• 137005-64-2 ((R)-1-{(S)-2-[4-(4-Acetyl-phenyl)-piperazin-1-yl]-1-benzyl-2-oxo-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid tert-butyl ester 
• 137005-65-3 {(R)-1-[(S)-2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-1-benzyl-2-oxo-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid tert-butyl ester 
• 77302-94-4 (S)-2-{(S)-4-Benzyloxycarbonyl-2-[(S)-4-benzyloxycarbonyl-2-((R)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-butyrylamino]-butyrylamino}-4-methyl-pentanoic acid methyl ester 
• 77302-93-3 (R)-2-{(S)-4-Benzyloxycarbonyl-2-[(S)-4-benzyloxycarbonyl-2-((R)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-butyrylamino]-butyrylamino}-4-methyl-pentanoic acid methyl ester 
• 78834-52-3 BOC-D-Leu-D-Val-pNA 
• 99242-14-5 Boc-D-Leu-D-Phe-pNA 
• 123068-68-8 Boc-D-Leu-D-Phe-ACA 

Relevant articles and documents

Synthetic studies of dideminus. III. Syntheses of statine and isostatine stereoisomers

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Optical resolution of N-(t-butoxycarbonyl)leucine through mixed ligand complex formation with (R)-N-(2-pyridylmethyl)pipecolatocopper(II)

A copper(II) complex of (R)-N-(2-pyridylmethyl)pipecolate (pmpi) was prepared, and its structure was revealed by X-ray crystal structure analysis. Mixed ligand complexes were then prepared from this complex and (R)- and (S)-N-(t-butoxycarbonyl)leucinate (BocLeu). The (R)-BocLeu complex is less soluble in aqueous acetonitrile and more soluble in acetone than the (S)-BocLeu complex, and the reason was discussed on the basis of their structures. Recrystallization of the reaction mixture consisting of Cu(II) ion, pmpi, and (RS)-BocLeu from aqueous acetonitrile gave the (R)-BocLeu complex and that from acetone gave the (S)-BocLeu complex.

PROLINAMIDE DERIVATIVE AS THROMBIN INHIBITOR, PREPARATION METHOD AND APPLICATION THEREOF

Provided are a compound of formula (I), pharmaceutically acceptable salts thereof, preparation methods and applications thereof for inhibiting thrombin, and applications in the treatment and prevention of thrombin-mediated and thrombin-related diseases.