16879-02-0

Basic information

• Product Name: 6-Chloropyridn-2-ol
• Synonyms: 2(1H)-Pyridinone, 6-chloro-;2(1H)-Pyridinone,6-chloro-;2(1H)-Pyridone, 6-chloro-;2(1H)-Pyridone,6-chloro-;2-Chloro-6-pyridinol;2-Hydroxy-6-chloropyridine;6-Chloro-1H-pyridin-2-one;6-Chloro-2(1H)-pyridinone
• CAS NO: 16879-02-0
• Molecular Formula: C₅H₄ClNO
• Molecular Weight: 129.54
• EINECS: 240-909-1
• Product Categories: PYRIDINE;Pyridines, Pyrimidines, Purines and Pteredines;Chloropyridines;Halopyridines;alcohol|alkyl chloride
• Mol File: 16879-02-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 128-130 °C(lit.)
• Boiling Point: 206 °C
• Flash Point: 163°C
• Appearance: /
• Density: 1.35
• Vapor Pressure: 0.000338mmHg at 25°C
• Refractive Index: 1.4510 (estimate)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 7.33±0.10(Predicted)
• BRN: 108665
• CAS DataBase Reference: 6-Chloropyridn-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloropyridn-2-ol(16879-02-0)
• EPA Substance Registry System: 6-Chloropyridn-2-ol(16879-02-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-37/39-36
• WGK Germany: 3
• Hazardous Substances Data: 16879-02-0(Hazardous Substances Data)

Usage

Description

6-Chloropyridn-2-ol, also known as 6-chloro-2-hydroxypyridine, is a white powder chemical compound that is primarily used in the synthesis of various complexes due to its unique properties. It undergoes melt reactions with other compounds, such as Os2(O2CCH3)4CI2, to yield different products like Os2CI4(chp) and Os2Cl(chp)4.

Uses

Used in Chemical Synthesis:
6-Chloropyridn-2-ol is used as a key component in the synthesis of various chemical complexes, particularly those involving osmium. Its ability to undergo melt reactions at specific temperatures makes it a valuable compound in the creation of new materials with unique properties.
Used in Electrochemistry:
In the field of electrochemistry, 6-chloro-2-hydroxypyridine is utilized for studying the electrochemical properties of the complexes it forms with other elements, such as osmium. This helps in understanding the behavior of these complexes in different environments and their potential applications.
Used in Spectroscopic Studies:
6-Chloropyridn-2-ol is employed in the study of the spectroscopic properties of the complexes it forms. This allows researchers to gain insights into the electronic structure and bonding of these complexes, which can be useful in developing new materials with specific characteristics.
Used in X-ray Crystallography:
6-chloro-2-hydroxypyridine is used in the determination of the X-ray crystal structure of the complexes it forms. This information is crucial for understanding the three-dimensional arrangement of atoms within the complex and can provide valuable insights into its properties and potential applications.

InChI:InChI=1/C5H4ClNO/c6-4-2-1-3-5(8)7-4/h1-3H,(H,7,8)

Upstream product

• 4645-11-8 6-ethoxy-2-bromo-pyridine 
• 64-19-7 acetic acid 
• 17228-64-7 6-chloro-2-methoxypyridine 
• 2402-78-0 2,6-dichloropyridine 
• 3385-94-2 hexamethyldisilathiane 

Downstream Products

• 2402-78-0 2,6-dichloropyridine 
• 6515-38-4 3,5,6-trichloropyridin-2 ol 
• 108122-24-3 1-(6-hydroxy-2-pyridyl)piperazine 
• 122751-37-5 Z-Ala-OPyCl 
• 122751-38-6 Z-Val-O-PyCl 
• 122751-40-0 Z-Gln-OPyCl 
• 122751-41-1 Z-Asp(OBzl)-OPyCl 
• 122751-39-7 Z-Phe-OPyCl 
• 125320-81-2 Dicyclohexyl-amine; compound with 6-chloro-pyridin-2-ol 
• 74546-79-5 Phenyl-phosphonothioic acid O,O-bis-(6-chloro-pyridin-2-yl) ester 
• 1185506-80-2 3,24-bis(6-chloropyridin-2-yloxy)-3α,5β-cholane 
• 1330074-66-2 C₁₇H₁₆ClNO 
• 1330074-78-6 C₁₇H₁₈ClNO 
• 1330074-80-0 C₁₆H₁₅Cl₂NO 

Relevant articles and documents

Quantitative Model of Solvent Effects on Hydroxypyridine-Pyridone and Mercaptopyridine-Thiopyridone Equilibria: Correlation with Reaction-Field and Hydrogen-Bonding Effects

A model for the effect of reaction field and hydrogen bonding on the relative energies of protomers is applied to the equilibria between 6-chloro-2-hydroxypyridine and 6-chloro-2-pyridone, 2-mercaptopyridine and 2-thiopyridone, 6-chloro-2-mercaptopyridine and 6-chloro-2-thiopyridone, and 4-mercaptopyridine and 4-thiopyridone in a wide range of solvents.Quantitative correlation is obtained by a multivariable analysis.In addition to satisfactory statistical tests of the correlations, estimates of the differences in free energies between the isomers in the vapor phase and of the dipole moment component of the reaction-field term are obtained which compare well with the available independent values.These criteria are shown to signal an unacceptable correlation for the case of 2-chloro-4-hydroxypyridine and 2-chloro-4-pyridone.The advantage of this model, which provides an understanding of the effect of molecular environment on protomeric equilibria in terms of reasonable physical interactions, over empirical approaches is noted.

One-pot synthesis of benzo[f]quinolin-3-ones and benzo[a]phenanthridein-5- ones by the photoanuulation of 6-chloropyridin-2-ones and 3-chloroisoquinolin-1- ones to phenylacetylene

The one-pot synthesis of benzo[f]quinolin-3-ones and benzo[a] phenanthridein-5-ones was achieved by the inter- and intramolecular photoannulation of 6-chloropyridin-2-ones and 3-chloroisoquinolin-1-ones with phenylacetylene or tethered phenylacetylene. The reactions were proceeded by photoaddition of 6-chloropyridin-2-ones and 3-chloroisoquinolin-1-ones to phenylacetylene to give the chlorine-substituted stilbenoids, and then 6π electrocyclization of the stilbenoids and oxidation aromatization to afford the polycyclic products.

Demethylation of methoxypyridines with sodium trimethylsilanethiolate

Demethylation of methoxypyridines was accomplished in 55-87percent yield by use of ca. 1.5-2.5 equivalents of NaSSiMe3 in 1,3-dimethyl-2-imidazolidinone at 120-180 deg C.This method was found applicable to a methoxyquinoline and methoxypyridines containing a second substituent, such as Cl, OMe, and COOMe.