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CAS

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16503-32-5

Brevilin A is a primary reference substance with assigned absolute purity, which is determined by considering chromatographic purity, water, residual solvents, and inorganic impurities. It is produced by PhytoLab GmbH & Co. KG and can be used for selective extraction to obtain natural substances and for preparing derivatives for anti-cancer activity.

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  • 16503-32-5 Structure

  • Basic information

    1. Product Name: Brevilin A
    2. Synonyms: Brevilin A
    3. CAS NO:16503-32-5
    4. Molecular Formula: C20H26O5
    5. Molecular Weight: 346.41744
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 16503-32-5.mol
    9. Article Data: 0

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 494.0±45.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.17±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: Brevilin A(CAS DataBase Reference)
    10. NIST Chemistry Reference: Brevilin A(16503-32-5)
    11. EPA Substance Registry System: Brevilin A(16503-32-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 16503-32-5(Hazardous Substances Data)

16503-32-5 Usage

Uses

Used in Pharmaceutical Industry:
Brevilin A is used as a reference substance for the development and standardization of natural products and their derivatives. Its high purity makes it a valuable tool for researchers and manufacturers in the pharmaceutical industry.
Used in Cancer Research:
Brevilin A is used as a starting material for the preparation of derivatives with potential anti-cancer activity. These derivatives can be further studied and developed for their therapeutic potential against various types of cancer.
Used in Natural Product Extraction:
Brevilin A can be selectively extracted from natural sources to obtain pure and concentrated forms of the substance. This selective extraction method is useful for obtaining natural substances for research and commercial applications.

Enzyme inhibitor

This naturally occurring sesquiterpenoid (FW = 346.40 g/mol; CAS 16503- 32-5) from the volatile oils of the plant Centipeda minima inhibits (IC50 = 10 μg/mL) STAT3 phosphorylation in the Jak/STAT signal transduction pathway of A549R cells. Brevilin A showed high specificity on Janus Kinase activity and following STAT3 signaling without directly affecting some other signals, including p65, AKT and GSK-3β phosphorylation, as well as Src kinase activity. Brevilin A is also an antibiotic with activity against Giardia (IC50 = 16 μM) and Entamoeba histolitica (IC50 = 4–9 μM).

Check Digit Verification of cas no

The CAS Registry Mumber 16503-32-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,5,0 and 3 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 16503-32:
(7*1)+(6*6)+(5*5)+(4*0)+(3*3)+(2*3)+(1*2)=85
85 % 10 = 5
So 16503-32-5 is a valid CAS Registry Number.

16503-32-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (3S,3aR,4S,4aR,7aR,8R,9aR)-3,4a,8-Trimethyl-2,5-dioxo-2,3,3a,4,4a ,5,7a,8,9,9a-decahydroazuleno[6,5-b]furan-4-yl (2Z)-2-methyl-2-bu tenoate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16503-32-5 SDS

16503-32-5Upstream product

16503-32-5Downstream Products

16503-32-5Related news

Brevilin A (cas 16503-32-5) induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation08/07/2019

Brevilin A is a sesquiterpene lactone isolated from Centipeda minima and possesses inhibitory effects on proliferation of various tumor cells. In this study, Brevilin A inhibitory effect on proliferation and its molecular mechanism of action were investigated both in vivo and in vitro in colon a...detailed

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