16409-34-0 Usage
Description
GLYCODEOXYCHOLIC ACID SODIUM SALT, also known as Sodium glycodeoxycholate, is a bile salt that can be used to form biomimicking environments. It is a solid substance and exists in bile in the form of combining with glycine or taurine to form glycodeoxycholic acid or sodium taurodeoxycholate. It is derived from cholanoic acid, which forms many organic compounds and stable molecular compounds.
Uses
Used in Pharmaceutical Industry:
GLYCODEOXYCHOLIC ACID SODIUM SALT is used as a component in developing mimetic intestinal fluids that are more similar to physiological fluids than those developed by mixed bile salt systems (MBS). This helps in studying the absorption and metabolism of drugs in the gastrointestinal tract.
Used in Scientific Research:
GLYCODEOXYCHOLIC ACID SODIUM SALT is used as a research tool to investigate the Ca2+ buffering capability of bile salt micelles. This helps in understanding the role of bile salts in the solubilization and transport of lipids in the body.
Synthesis
Sodium deoxyglycolic acid is easily soluble in water and has a strong surface activity. It can be used to destroy cells to extract enzymes. Sodium deoxyglycolic acid is not directly biosynthesized by cholesterol, but is metabolized by intestinal bacteria. Synthesized from cholic acid.
Biochem/physiol Actions
Induces apoptosis in hepatocytes; may induce DNA cleavage.
Check Digit Verification of cas no
The CAS Registry Mumber 16409-34-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,4,0 and 9 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 16409-34:
(7*1)+(6*6)+(5*4)+(4*0)+(3*9)+(2*3)+(1*4)=100
100 % 10 = 0
So 16409-34-0 is a valid CAS Registry Number.
InChI:InChI=1/C26H43NO5.Na/c1-15(4-9-23(30)27-14-24(31)32)19-7-8-20-18-6-5-16-12-17(28)10-11-25(16,2)21(18)13-22(29)26(19,20)3;/h15-22,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32);/t15-,16-,17-,18+,19-,20+,21+,22+,25+,26-;/m1./s1
16409-34-0Relevant articles and documents
Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts
Venturoni, Francesco,Gioiello, Antimo,Sardella, Roccaldo,Natalini, Benedetto,Pellicciari, Roberto
experimental part, p. 4109 - 4115 (2012/06/15)
A multi-gram scale protocol for the N-acyl amidation of bile acids with glycine and taurine has been successfully developed under continuous flow processing conditions. Selecting ursodeoxycholic acid (UDCA) as the model compound and N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) as the condensing agent, a modular mesoreactor assisted flow set-up was employed to significantly speed up the optimization of the reaction conditions and the flow scale-up synthesis. The results in terms of yield, in line purification, analysis, and implemented flow set-up for the reaction optimization and large scale production are reported and discussed.
