1616342-45-0

Basic information

• Product Name: (2R,5S,13aR)-8-methoxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxylic acid
• Synonyms: (2R,5S,13aR)-8-methoxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxylic acid;(2R,5S)-8-methoxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxylic acid
• CAS NO: 1616342-45-0
• Molecular Formula: C₁₅H₁₆N₂O₆
• Molecular Weight: 320.29734
• Mol File: 1616342-45-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 591.5±50.0 °C(Predicted)
• Appearance: /
• Density: 1.58±0.1 g/cm3(Predicted)
• PKA: 5.52±0.20(Predicted)
• CAS DataBase Reference: (2R,5S,13aR)-8-methoxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,5S,13aR)-8-methoxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxylic acid(1616342-45-0)
• EPA Substance Registry System: (2R,5S,13aR)-8-methoxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxylic acid(1616342-45-0)

Safety Data

• Hazardous Substances Data: 1616342-45-0(Hazardous Substances Data)

Usage

General Description

The chemical compound "(2R,5S,13aR)-8-methoxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxylic acid" is a complex organic molecule with a long and specific molecular structure. It contains a methoxy group, two carbonyl groups, and a carboxylic acid group. The compound also has an octahydro backbone with a pyrido pyrazino oxazepine ring system. Due to its intricate structure, this chemical may have various potential applications, including pharmaceutical and medicinal uses, where its specific structure could interact with biological systems to produce desired effects. Additionally, its complex nature may make it valuable for research and study in organic chemistry and drug development.

Upstream product

• 41051-15-4 4-methoxyacetoacetic acid methylester 
• 1110772-05-8 (1R,3S)-3-aminocyclopentan-1-ol 
• 1335210-23-5 1-[2,2-bis(methyloxy)ethyl]-5-(methyloxy)-6-[(methyloxy)carbonyl]-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid 
• 1616340-75-0 1-(2,2-dihydroxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid 

Downstream Products

• 1611493-60-7 GS-9883 
• 1616340-44-3 (2R,13aR)-8-hydroxy-7,9-dioxo-N-((R)-1-(2,4,6-trifluorophenyl)ethyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1 ',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide 
• 1616340-19-2 (2R,5S,13aR)-N-(2-cyclopropoxy-4-fluorobenzyl)-8-hydroxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide 
• 1616342-31-4 C₂₅H₂₆FN₃O₆ 
• 1616341-30-0 C₂₃H₂₂F₃N₃O₅ 
• 1616340-94-3 (2R,5S,13aR)-8-methoxy-7,9-dioxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1‘,2’:4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide 

Relevant articles and documents

CONTINUES FLOW PROCESS FOR THE PREPARATION OF ACTIVE PHARMACEUTICAL INGREDIENTS - POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVES AND INTERMEDIATES THEREOF

The present invention discloses continues flow process for the preparation of polycyclic carbamoyl pyridone derivatives and intermediates thereof. In particular, the present invention discloses a process for the preparation of intermediate. Formule (V).

POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE

Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Ζ1 and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.