15862-31-4

Basic information

• Product Name: 2-Amino-3-bromo-5-nitropyridine
• Synonyms: 3-BROMO-5-NITROPYRIDIN-2-AMINE;2-PYRIDINAMINE, 3-BROMO-5-NITRO-;2-AMINO-3-BROMO-5-NITROPYRIDINE;AURORA KA-367;2-Amino-3-bromo-5-nitropyridine 98%;2-Amino-3-bromo-5-nitropyridine,98%;2-AMino-3-broMo-5-nitropyridine, 98% 1GR
• CAS NO: 15862-31-4
• Molecular Formula: C₅H₄BrN₃O₂
• Molecular Weight: 218.01
• EINECS: -0
• Product Categories: Amines;blocks;Bromides;Pyridines;Pyridine;Boronic Acid;Amino-pyridine series;amine| alkyl bromide| nitro-compound
• Mol File: 15862-31-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 215-219 °C
• Boiling Point: 347.3 °C at 760 mmHg
• Flash Point: 163.8 °C
• Appearance: Beige to orange-brown/Powder
• Density: 1.9128 (rough estimate)
• Vapor Pressure: 5.45E-05mmHg at 25°C
• Refractive Index: 1.6200 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 0.06±0.49(Predicted)
• CAS DataBase Reference: 2-Amino-3-bromo-5-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-bromo-5-nitropyridine(15862-31-4)
• EPA Substance Registry System: 2-Amino-3-bromo-5-nitropyridine(15862-31-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 15862-31-4(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-Amino-3-bromo-5-nitropyridine is used as a synthetic intermediate for the development of various organic compounds. Its unique structure allows for further functionalization and modification, which can be utilized in the creation of pharmaceuticals, agrochemicals, and other specialty chemicals. The presence of the amino, bromine, and nitro groups provides multiple points for chemical reactions, enabling the synthesis of a wide range of products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Amino-3-bromo-5-nitropyridine is used as a building block for the synthesis of novel drug candidates. Its versatile chemical properties allow for the development of compounds with potential therapeutic applications, such as new antibiotics, antivirals, or anticancer agents. The compound's reactivity can be exploited to create molecules with specific biological activities, targeting various diseases and conditions.
Used in Agrochemical Industry:
2-Amino-3-bromo-5-nitropyridine also finds application in the agrochemical industry, where it is used as a starting material for the synthesis of new pesticides, herbicides, and insecticides. Its unique structure can be tailored to create compounds with improved efficacy, selectivity, and environmental compatibility, addressing the growing demand for sustainable and effective crop protection solutions.

InChI:InChI=1/C5H4BrN3O2/c6-4-1-3(9(10)11)2-8-5(4)7/h1-2H,(H2,7,8)/p+1

Upstream product

• 4214-76-0 5-nitro-pyridin-2-ylamine 
• 504-29-0 2-aminopyridine 
• 35486-42-1 2-amino-3,5-dibromopyridine 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 

Downstream Products

• 896161-09-4 N-(5-amino-3-bromopyridin-2-yl)acetamide 
• 1186367-90-7 3-fluoro-N-(6-oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-2-yl)-benzamide 
• 1186367-93-0 [3-bromo-5-(3-fluoro-benzoylamino)-pyridin-2-yl]-carbamic acid tert-butyl ester 
• 896114-91-3 5-nitro-2-phenyl-1H-pyrrolo[2,3-b]pyridine 
• 896116-37-3 2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-amine 
• 896160-69-3 3-bromopyridine-2,5-diamine 
• 1169433-15-1 3-((4-fluorophenyl)ethynyl)-5-nitropyridin-2-amine 
• 1616388-27-2 isopropyl 5-[(4,5-dimethyl-1H-pyrazole-3-carbonyl)amino]-2-(4-fluorophenyl)pyrrolo[2,3-b]pyridine-1-carboxylate 
• 1616385-66-0 2-(4-fluorophenyl)-N-[(5-methyl-1H-pyrazol-3-yl)methyl]-1H-pyrrolo[2,3-b]pyridin-5-amine 
• 1616386-96-9 N-[(4-chloro-5-methyl-1H-pyrazol-3-yl)methyl]-2-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-5-amine 
• 1616385-50-2 N-[2-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-3,4-dimethyl-1H-pyrazole-5-carboxamide 
• 1616387-98-4 2-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-5-amine 
• 1616387-97-3 3-((4-fluorophenyl)ethynyl)pyridine-2,5-diamine 
• 1428799-39-6 C₁₁H₈BrN₃O₂ 

Relevant articles and documents

Effect of the 3-halo substitution of the 2′-deoxy aminopyridinyl-pseudocytidine derivatives on the selectivity and stability of antiparallel triplex DNA with a CG inversion site

Triplex formation against a target duplex DNA has the potential to become a tool for the genome research. However, there is an intrinsic restriction on the duplex DNA sequences capable of forming the triplex DNA. Recently, we demonstrated the selective fo

AZAINDOLE DERIVATIVES AS CFTR MODULATORS

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.