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1586-00-1

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1586-00-1 Usage

Chemical Properties

WHITE CRYSTALLINE MASS

Check Digit Verification of cas no

The CAS Registry Mumber 1586-00-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,5,8 and 6 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1586-00:
(6*1)+(5*5)+(4*8)+(3*6)+(2*0)+(1*0)=81
81 % 10 = 1
So 1586-00-1 is a valid CAS Registry Number.
InChI:InChI=1/C14H14O/c15-11-14-9-5-4-8-13(14)10-12-6-2-1-3-7-12/h1-9,15H,10-11H2

1586-00-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name (2-benzylphenyl)methanol

1.2 Other means of identification

Product number -
Other names 2-Benzylbenzyl alcohol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1586-00-1 SDS

1586-00-1Relevant articles and documents

Negishi cross-coupling with functionalised organozinc compounds prepared by lithium-zinc transmetallation

Yus, Miguel,Gomis, Joaquín

, p. 5721 - 5724 (2001)

The reaction of some functionalised organolithium compounds 2 (easily prepared by DTBB-catalysed lithiation of isochroman, phthalan and 2,3-dihydrobenzofuran) with an equimolecular amount of zinc bromide followed by reaction with an aryl or alkenyl bromide in the presence of a catalytic amount of Pd(PPh3)4 or Pd(PPh3)2(OAc)2 (5 mol%) under THF reflux overnight gave the expected cross-coupling compounds. These arylation or alkenylation processes, which work also with iodinated substrates, are not possible in the absence of the zinc or palladium compounds under the same reaction conditions.

Synthesis of Benzoazepine Derivatives via Azide Rearrangement and Evaluation of Their Antianxiety Activities

Lapmanee, Sarawut,Palavong, Nitwaree,Reamtong, Onrapak,Ruchirawat, Somsak,Thongsornkleeb, Charnsak,Tummatorn, Jumreang

supporting information, p. 1449 - 1458 (2021/09/13)

A new synthetic method for the construction of benzoazepine analogues has been developed employing ortho-arylmethylbenzyl azide derivatives as precursors using an azide rearrangement reaction. In this work, 14 benzoazepine compounds were successfully synthesized in moderate to excellent yields. All synthetic benzoazepines were evaluated for their cytotoxicity against normal human kidney cell line (HEK cell). The results showed that compound 18c had the lowest cytotoxicity (IC50 = 65.68 μM) among tested compounds, which was comparable with the antianxiety drug diazepam (IC50 = 87.90 μM). Based on the cytotoxicity results, five benzoazepine analogues (compounds 18c, 18h, 18j, 18n, and 18p) were selected to determine the antianxiety effect on stressed rats using elevated plus maze (EPM) and open field test (OFT) methods. Interestingly, compound 18c showed better anxiolytic activity than diazepam without a sedative effect by showing superior hyperlocomotor activity. Therefore, this discovery could pave the way for drug development to treat patients with anxiety disorder.

Cyclic analogue of S-benzylisothiourea that suppresses kynurenine production without inhibiting indoleamine 2,3-dioxygenase activity

Fukuda, Miwa,Sasaki, Tomomi,Hashimoto, Tomoko,Miyachi, Hiroyuki,Waki, Minoru,Asai, Akira,Takikawa, Osamu,Ohno, Osamu,Matsuno, Kenji

supporting information, p. 2846 - 2849 (2018/07/30)

Kynurenine is biosynthesised from tryptophan catalysed by indoleamine 2,3-dioxygenase (IDO). The abrogation of kynurenine production is considered a promising therapeutic target for immunological cancer treatment. In the course of our IDO inhibitor programme, formal cyclisation of the isothiourea moiety of the IDO inhibitor 1 afforded the 5-Cl-benzimidazole derivative 2b-6, which inhibited both recombinant human IDO (rhIDO) activity and cellular kynurenine production. Further derivatisation of 2b-6 provided the potent inhibitor of cellular kynurenine production 2i (IC50 = 0.34 μM), which unexpectedly exerted little effect on the enzymatic activity of rhIDO. Elucidation of the mechanism of action revealed that compound 2i suppresses IDO expression at the protein level by inhibiting STAT1 expression in IFN-γ-treated A431 cells. The kynurenine-production inhibitor 2i is expected to be a promising starting point for a novel approach to immunological cancer treatment.

Effect of mesoporosity on selective benzylation of aromatics with benzyl alcohol over mesoporous ZSM-5

Jin, Hailian,Ansari, Mohd Bismillah,Jeong, Eun-Young,Park, Sang-Eon

experimental part, p. 55 - 62 (2012/08/13)

The effect of mesoporosity on product distribution in benzylation of aromatics such as benzene, toluene, anisole and mesitylene with benzyl alcohol was investigated over various ZSM-5 catalysts with different degree of mesoporosity, which were prepared by microwave-induced assembly via ionic interaction between sulfonic acid-functionalized or non-functionalized ZSM-5 nanozeolites and counter cationic surfactant, and hydrothermal synthesis with or without sulfonic acid functionalization and surfactant. The product distribution of the aromatic benzylation was found to vary with the different mesoporosity. The selectivity of desired monobenzylated aromatic was increased from 19.8% to 75.5% with increasing mesopore volume from 0.11 to 0.75 cm 3/g. Meso ZSM-5 (SO3H-CTAB)-MW with the highest external acid sites and mesopore volume showed better conversion as well as much higher selectivity of desired bulky monobenzylated aromatics than those of other catalysts, whereas microporous ZSM-5 mainly showed dibenzyl ether as major product due to diffusion limitation of bulky product.

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