15845-66-6Relevant articles and documents
The relative hydrolytic reactivities of pyrophosphites and pyrophosphates
Mistry, Dharmit,Powles, Nicholas
, p. 5727 - 5733 (2013/09/12)
The pH-rate profiles for the hydrolysis of pyrophosphate (PP(v)) and pyrophosphite (PP(iii), pyro-di-H-phosphonate) are a complex function of pH, reflecting the different ionic species and their relative reactivities. PP(iii) is more reactive than PP(v) at all pHs and only PP(iii) shows a hydroxide-ion reaction at high pH, so it is 1010-fold more reactive than PP(v) in 0.1 M NaOH. The pKa2 of PP(iii) ～0.44, so the dominant species at pH's > 1 is the di-anion PP(iii)2-. Although there is no observable (NMR or ITC) binding of Mg2+ to the PP(iii) di-anion there is a modest increase in the rate of hydrolysis of PP(iii) by Mg2+. PP(iii) is neither a substrate nor an inhibitor of pyrophosphatase, the enzyme that efficiently catalyses the hydrolysis of PP(v).
PROCESS FOR THE MANUFACTURE OF DIALKYLPHOSPHITES
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Page/Page column 8, (2010/12/26)
A process for the manufacture of dialkyl phosphites is disclosed. In detail, dialkyl phosphites are prepared starting from P4O6, or partially hydrated species thereof cumulatively P-O, by reacting specific molar ratios of alcohol and P-O, containing from 1 to 6 P-O-P bonds in the molecule, in the presence of trialkylphospite (TAP) to thus yield high purity and high yield of dialkyl phosphites. The P-O reactant is preferably represented by liquid P4O6.
Aryl H-phosphonates. 7. Studies on the formation of phosphorus-carbon bond in the reaction of trityl and benzyl halides with dialkyl and diphenyl H-phosphonates
Kers, Annika,Stawinski, Jacek,Dembkowski, Leszek,Kraszewski, Adam
, p. 12691 - 12698 (2007/10/03)
The reactions of H-phosphonate diesters with trityl and benzyl halides were investigated using 31P NMR spectroscopy. It was found that extensive oxidation, which usually accompanies the formation of trityl- or p-nitrobenzylphosphonates from the corresponding alkyl bromides in the Michaelis-Becker reaction, can be considerably suppressed or completely eliminated by reacting p-nitrobenzyl or trityl bromides with diphenyl H-phosphonate in acetonitrile in the presence of DBU.
