158076-68-7Relevant articles and documents
Synthesis and characterization of hydroxylated polychlorinated biphenyls (PCBs) identified in human serum
Safe,Safe, Stephen,Washburn,Washburn, Kent,Zacharewski,Zacharewski, Timothy,Phillips,Phillips, Timothy
, p. 3017 - 3023 (2007/10/03)
Hydroxylated polychlorinated biphenyls (PCBs) have been identified in wildlife and human samples. Most of these compounds are highly chlorinated (penta-hepatachloro) and contain a single meta- or para-hydroxyl group. Using the Cadogan coupling procedure, the following hydroxy-PCBs congeners were synthesized: 2,3,3',4',5-pentachloro-4-biphenylol, 2,3',4,4',5-pentachloro-3-biphenylol, 2',3,3',4',5-pentachloro-4-biphenylol, 2,2',3',4,4'-pentachloro-3-biphenylol, 2,2',3,3',4',5-pentachloro-4-biphenylol, 2,2',3',4,4',5-hexachloro-3-biphenylol, 2,2',3,4',5,5'-hexachloro-4-biphenylol, 2,2',3,3',4',5,5'-heptachloro-4-biphenyl 2,2',3',4,4',5,5'-heptachloro-3-biphenylol, 2,2',3,4',5,5',6-heptachloro-4-biphenylol. Many of these compounds have been detected as residues in human serum and current studies are investigating their activities as agonists and antagonists for several endocrine-mediated responses.