153624-38-5 Usage
Description
4-Isobutylphenylboronic acid is an organic compound characterized by its white solid appearance. It is a boronic acid derivative with the chemical structure featuring an isobutyl group attached to a phenyl ring, which is connected to a boronic acid group. 4-Isobutylphenylboronic acid is known for its significant role in the synthesis of various pharmaceutical compounds and has demonstrated potential applications in the medical field.
Uses
Used in Pharmaceutical Industry:
4-Isobutylphenylboronic acid is used as an intermediate in the synthesis of thiophenesulfonamides, which are known as endothelin receptor antagonists. These antagonists play a crucial role in treating various medical conditions, such as hypertension and other cardiovascular diseases, by blocking the action of endothelin, a potent vasoconstrictor.
4-Isobutylphenylboronic acid is also used as a key component in the synthesis of thalidomide analogs. These analogs exhibit the ability to inhibit the expression of the proinflammatory cytokine Tumor Necrosis Factor (TNF). TNF plays a significant role in the inflammatory response and is associated with various diseases, including autoimmune disorders and cancer. By inhibiting TNF expression, thalidomide analogs can potentially help in the treatment of these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 153624-38-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,3,6,2 and 4 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 153624-38:
(8*1)+(7*5)+(6*3)+(5*6)+(4*2)+(3*4)+(2*3)+(1*8)=125
125 % 10 = 5
So 153624-38-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H15BO2/c1-8(2)7-9-3-5-10(6-4-9)11(12)13/h3-6,8,12-13H,7H2,1-2H3
153624-38-5Relevant articles and documents
PHENYL SULFONAMIDE ENDOTHELIN ANTAGONISTS
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, (2008/06/13)
Compounds of the formula STR1 inhibit the activity of endothelin. The symbols are defined as follows: R 1, R 2 and R. sup.3 are each independently(a) hydrogen, except that R. sup.1 is other than hydrogen;(b) alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aryloxy, aralkyl or aralkoxy, any of which may be substituted with Z 1, Z 2 and Z. sup.3 ;(c) halo;(d) hydroxyl;(e) cyano; (f) nitro; (g)--C(O)H or--C(O)R 6 ;(h)--CO 2 H or--CO 2 R 6 ; (i)--SH,--S(O) n R 6,--S(O) m--OH,--S(O) m--OR 6,--O--S(O) m--R 6,--O--S(O) m OH or--O--S(O) m--OR. sup.6 ;(j)--Z. sup.4--NR 7 R 8 ; or (k)--Z 4--N(R 11--Z 5--NR 9 R 10 ; and the remaining symbols are as defined in the specification.