153034-82-3

Basic information

• Product Name: 4-IODO-2-FLUORO-3-FORMYLPYRIDINE
• Synonyms: 2-FLUORO-4-IODONICOTINALDEHYDE;2-FLUORO-4-IODOPYRIDINE-3-CARBOXALDEHYDE;4-IODO-2-FLUORO-3-FORMYLPYRIDINE;2-FLUORO-3-FORMYL-4-IODOPYRIDINE;2-Fluoro-4-iodo-3-pyridinecarboxaldehyde;2 - F -3 - aldehyde -4 - iodine pyridine;2-fluoro-4-iodonicotaldehyde;2-Fluoro-4-iodopyridine-3-carbaldehyde
• CAS NO: 153034-82-3
• Molecular Formula: C₆H₃FINO
• Molecular Weight: 251
• Product Categories: Pyridine;Pyridines;Fluorine series
• Mol File: 153034-82-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 304.229 °C at 760 mmHg
• Flash Point: 137.793 °C
• Appearance: /
• Density: 2.081 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.65
• Storage Temp.: Room temperature.
• PKA: -3.62±0.18(Predicted)
• CAS DataBase Reference: 4-IODO-2-FLUORO-3-FORMYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-IODO-2-FLUORO-3-FORMYLPYRIDINE(153034-82-3)
• EPA Substance Registry System: 4-IODO-2-FLUORO-3-FORMYLPYRIDINE(153034-82-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 153034-82-3(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 58, p. 7832, 1993 DOI: 10.1021/jo00079a031

InChI:InChI=1/C6H3FINO/c7-6-4(3-10)5(8)1-2-9-6/h1-3H

Upstream product

• 22282-70-8 2-fluoro-4-iodopyridine 
• 109-94-4 formic acid ethyl ester 
• 372-48-5 2-fluoropyridine 
• 168428-74-8 2-fluoro-4-iodo-3-pyridyllithium 
• 113975-22-7 2-fluoro-3-iodopyridine 

Downstream Products

• 884494-84-2 methyl 2-fluoro-4-iodonicotinate 
• 861881-02-9 4-iodo-1H-pyrazolo[3,4-b]pyridine 
• 609771-42-8 5-ethyl-1-fluoro-6,7-dihydro-5H-[2]pyrindine-5,7-diol 
• 1198437-88-5 4-iodo-1-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyridine 
• 913378-51-5 4-iodo-2-oxo-1-phenyl-1,2-dihydropyridine-3-carbonyl chloride 
• 913378-48-0 methyl 4-iodo-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxylate 
• 1629023-85-3 C₃₆H₂₄BrF₃N₄ 

Relevant articles and documents

NOVEL ISOINDOLINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF

Disclosed are a novel isoindoline derivative, a pharmaceutical composition and use thereof. The compound of formula I, or the pharmaceutically acceptable salt, solvate, polymorph, co-crystal, stereoisomer, isotopic compound, metabolite or prodrug thereof disclosed in the invention can regulate the generation and/or activity of PDE4 and/or TNF-α so as to effectively treat cancer and inflammatory diseases.

PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS

Compounds of the general formula(I): (I) processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

First Metalation of Aryl Iodides: Directed Ortho-Lithiation of Iodopyridines, Halogen-Dance, and Application to Synthesis

Metalation of iodopyridines was succesfully achieved by LDA at low temperature.In many cases, lithiation is ortho directed by the iodo group which subsequently ortho-migrates very fast to give stabilized iodolithiopyridines.This procedure was applied to 2