152126-31-3

Basic information

• Product Name: 3-FLUOROPYRIDINE-2-CARBOXYLIC ACID
• Synonyms: 3-FLUOROPYRIDINE-2-CARBOXYLIC ACID;3-FLUOROPICOLINIC ACID;3-Fluoropyridine-2-carboxylicacid98%;2-Pyridinecarboxylicacid,3-fluoro-(9CI);3-fluropyridine-2-carboxylic acid;3-FLUOROPICOLINIC ACID / 3-FLUOROPYRIDINE-2-CARBOXYLIC ACID;3-FLUOROPYRIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE;3-Fluoro-2-pyridinecarboxylic acid
• CAS NO: 152126-31-3
• Molecular Formula: C₆H₄FNO₂
• Molecular Weight: 141.1
• Product Categories: CARBOXYLICACID;PYRIDINE;Building Blocks;Carboxy;Pyridines
• Mol File: 152126-31-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 154°C
• Boiling Point: 265.2 °C at 760 mmHg
• Flash Point: 114.2 °C
• Appearance: /
• Density: 1.419 g/cm³
• Vapor Pressure: 0.00465mmHg at 25°C
• Refractive Index: 1.541
• Storage Temp.: Room temperature.
• PKA: 2.71±0.10(Predicted)
• CAS DataBase Reference: 3-FLUOROPYRIDINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUOROPYRIDINE-2-CARBOXYLIC ACID(152126-31-3)
• EPA Substance Registry System: 3-FLUOROPYRIDINE-2-CARBOXYLIC ACID(152126-31-3)

Safety Data

• Hazard Codes: Xi,Xn
• HazardClass: IRRITANT
• Hazardous Substances Data: 152126-31-3(Hazardous Substances Data)

Usage

Description

3-Fluoropyridine-2-carboxylic acid is a fluorinated pyridine derivative, characterized by its unique structure that includes a pyridine ring, an aromatic heterocyclic compound, with a fluorine atom at the 3-position and a carboxylic acid group at the 2-position. This chemical compound is often utilized in scientific research, particularly in the field of organic chemistry, as a building block for the synthesis of more complex compounds. It is generally available as a light yellow to brown crystalline powder and has the molecular formula C6H4FNO2.

Uses

Used in Organic Chemistry Research:
3-Fluoropyridine-2-carboxylic acid is used as a building block for the synthesis of more complex compounds, particularly in the field of organic chemistry. Its unique properties, due to the presence of a fluorine atom and carboxylic acid group, make it a valuable component in the creation of new chemical entities.
Used in Pharmaceutical Development:
3-Fluoropyridine-2-carboxylic acid is used as a key intermediate in the development of pharmaceutical compounds. Its structural features allow for the design of new drugs with potential therapeutic applications, taking advantage of the electronegativity and reactivity of the fluorine atom and the functional group versatility of the carboxylic acid.
Used in Material Science:
3-Fluoropyridine-2-carboxylic acid is used as a component in the synthesis of advanced materials, such as polymers and coatings, that can benefit from the properties conferred by the fluorine atom and the carboxylic acid group. This can lead to materials with improved performance characteristics, such as increased stability, durability, or specific interactions with other molecules.
Used in Agrochemicals:
3-Fluoropyridine-2-carboxylic acid is used as a starting material in the synthesis of agrochemicals, such as pesticides and herbicides. The incorporation of the fluorine atom and carboxylic acid group can enhance the effectiveness of these compounds, potentially leading to more efficient and targeted agricultural products.

InChI:InChI=1/C6H4FNO2/c7-4-2-1-3-8-5(4)6(9)10/h1-3H,(H,9,10)

Upstream product

• 372-47-4 3-Fluoropyridine 
• 141-78-6 ethyl acetate 
• 2546-56-7 4-chloro-3-fluoro-pyridine 
• 860296-21-5 4-chloro-3-fluoropyridine-2-carboxylic acid 
• 124-38-9 carbon dioxide 

Downstream Products

• 869108-35-0 methyl 3-fluoropyridine-2-carboxylate 
• 31181-79-0 (3-fluoropyridin-2-yl)methanol 
• 122307-44-2 2-(bromomethyl)-3-fluoropyridine 
• 929569-15-3 (3-fluoropyridin-2-yl)-[5-hydroxy-1-(4-methoxybenzyl)-1H-pyrazol-4-yl]methanone 
• 929569-02-8 1-(4-methoxybenzyl)pyrazolo[4',3':5,6]pyrano[3,2-b]pyridin-4(1H)-one 
• 929569-00-6 3-methyl-1-phenylpyrazolo[4',3':5,6]pyrano[3,2-b]pyridin-4(1H)-one 
• 929569-01-7 1-phenylpyrazolo[4',3':5,6]pyrano[3,2-b]pyridin-4(1H)-one 
• 1352794-83-2 4-(3-fluoro-2-pyridinyl)benzonitrile 
• 1246461-83-5 4-(3-fluoro-2-pyridinyl)benzoic acid ethyl ester 
• 1233702-02-7 2-(4-chlorophenyl)-3-fluoropyridine 

Relevant articles and documents

The discovery of potent small molecule cyclic urea activators of STING

STING mediates innate immune responses that are triggered by the presence of cytosolic DNA. Activation of STING to boost antigen recognition is a therapeutic modality that is currently being tested in cancer patients using nucleic-acid based macrocyclic STING ligands. We describe here the discovery of 3,4-dihydroquinazolin-2(1H)-one based 6,6-bicyclic heterocyclic agonists of human STING that activate all known human variants of STING with high potency.

SPECIFIC CARBOXAMIDES AS KCNQ2/3 MODULATORS

The invention relates to specific carboxamides of formula (I) as KCNQ2/3 modulators, to processes for their preparation, to medicaments comprising these compounds and to the use of these compounds in the preparation of medicaments.

Reactivity of 1-(des-3-hydroxy-picolinoyl) pristinamycin I(A)

1-(Des-3-hydroxy-picolinoyl) pristinamycin I(A) (PI-NH2) was shown to undergo a variety of reactions, including two unexpected transformations, to afford new pristinamycin I(A) derivatives.