1517-96-0

Basic information

• Product Name: 5(4H)-Isoxazolone, 3-methyl-
• CAS NO: 1517-96-0
• Molecular Formula: C4H5NO2
• Molecular Weight: 99.0892
• Mol File: 1517-96-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5(4H)-Isoxazolone, 3-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 5(4H)-Isoxazolone, 3-methyl-(1517-96-0)
• EPA Substance Registry System: 5(4H)-Isoxazolone, 3-methyl-(1517-96-0)

Safety Data

• Hazardous Substances Data: 1517-96-0(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 21383-24-4 (5,6-diphenyl-[1,2,4]triazin-3-yl)-hydrazine 
• 16430-09-4 3-methyl-4-(1-phenylmethylidene)-5-isoxazolone 
• 3075-23-8 S-ethyl acetothioacetate 
• 27991-08-8 N-acetoacetylphenylhydroxyloamine 

Downstream Products

• 73841-59-5 3-methyl-4-(4-phenyl-piperazin-1-ylmethyl)-2H-isoxazol-5-one 
• 73841-61-9 4-[4-(4-chloro-phenyl)-piperazin-1-ylmethyl]-3-methyl-2H-isoxazol-5-one 
• 73841-60-8 3-methyl-4-(4-o-tolyl-piperazin-1-ylmethyl)-2H-isoxazol-5-one 
• 103906-10-1 4-(p-hydroxyphenylmethylidene)-3-methylisoxazol-5(4H)-one 
• 17975-50-7 4-(o-hydroxyphenylmethylidene)-3-methylisoxazol-5(4H)-one 
• 146795-08-6 4-(2,4-dimethoxyphenylmethylidene)-3-methylisoxazol-5(4H)-one 

Relevant articles and documents

A Continuous Flow Process for the Synthesis of Hymexazol

Hymexazol is an efficient and low-toxicity soil fungicide. In this work, a fully continuous flow process for the synthesis of hymexazol has been developed. This process begins with combining ethyl acetoacetate and hydroxylamine hydrochloride to form a hydroxamic acid intermediate. The reaction solution is then quenched with concentrated hydrochloric acid to obtain the final product, hymexazol. Under the optimized process conditions, the total yield of the target product reached 86%. In addition, production was successfully scaled-up to a kilogram scale. The continuous flow method not only greatly decreases the reaction time but also significantly inhibits the side reactions.

Synthesis of 3-isoxazolols revisited. Diketene and β-ketoesters as starting materials

-

Reaction of N-hydroxyacetoacetanilide with carbonyl reagents

-