149777-00-4

Basic information

• Product Name: TETRAHYDROPYRAN-4,4-DICARBOXYLIC ACID DIMETHYL ESTER
• Synonyms: TETRAHYDROPYRAN-4,4-DICARBOXYLIC ACID DIMETHYL ESTER;DIMETHYL TETRAHYDROPYRAN-4,4-DICARBOXYLATE;Tetrahydropyran-4,4-dicarboxylicAcidDimethylEst;4H-Pyran-4,4-dicarboxylicacid;DiMethyl dihydro-2H-pyran-4,4(3H)-dicarboxylate;Dimethyl tetrahydro-4H-pyran-4,4-dicarboxylate;Tetrahydro-2H-pyran-4,4-dicarboxylic acid dimethyl ester;Tetrahydro-4H-pyran-4,4-dicarboxylic acid dimethyl ester
• CAS NO: 149777-00-4
• Molecular Formula: C9H14O5
• Molecular Weight: 202.20446
• EINECS: 1308068-626-2
• Mol File: 149777-00-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 238.235°C at 760 mmHg
• Flash Point: 96.744°C
• Appearance: /
• Density: 1,18 g/cm3
• Vapor Pressure: 0.043mmHg at 25°C
• Refractive Index: 1.4530 to 1.4560
• Storage Temp.: 2-8°C
• CAS DataBase Reference: TETRAHYDROPYRAN-4,4-DICARBOXYLIC ACID DIMETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: TETRAHYDROPYRAN-4,4-DICARBOXYLIC ACID DIMETHYL ESTER(149777-00-4)
• EPA Substance Registry System: TETRAHYDROPYRAN-4,4-DICARBOXYLIC ACID DIMETHYL ESTER(149777-00-4)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 149777-00-4(Hazardous Substances Data)

Usage

Description

TETRAHYDROPYRAN-4,4-DICARBOXYLIC ACID DIMETHYL ESTER, with the molecular formula C10H16O5, is a colorless liquid chemical compound known for its slightly fruity odor and solubility in most organic solvents. It serves as a versatile building block in organic synthesis and holds promise as a pharmaceutical intermediate, playing a significant role in the field of organic chemistry.

Uses

Used in Organic Synthesis:
TETRAHYDROPYRAN-4,4-DICARBOXYLIC ACID DIMETHYL ESTER is used as a building block for the synthesis of various organic compounds, providing a foundation for the creation of complex molecules and contributing to the advancement of organic chemistry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, TETRAHYDROPYRAN-4,4-DICARBOXYLIC ACID DIMETHYL ESTER is utilized as a pharmaceutical intermediate, playing a crucial role in the development of new drugs and medicinal compounds. Its properties make it a valuable component in the synthesis of potential therapeutic agents.
It is important to handle TETRAHYDROPYRAN-4,4-DICARBOXYLIC ACID DIMETHYL ESTER with care, as it may cause irritation to the skin, eyes, and respiratory system, highlighting the need for proper safety measures during its use in various applications.

InChI:InChI=1/C9H14O5/c1-12-7(10)9(8(11)13-2)3-5-14-6-4-9/h3-6H2,1-2H3

Upstream product

• 5414-19-7 1,1'-oxybis(2-bromo-ethane) 
• 108-59-8 malonic acid dimethyl ester 

Downstream Products

• 923020-93-3 4-(methoxycarbonyl) dihydro-2H-pyran-4-carboxilic acid 
• 95283-42-4 4,4-bis-(toluene-4-sulfonyloxymethyl)-tetrahydro-pyran 
• 89975-77-9 (tetrahydro-2H-pyran-4,4-diyl)dimethanol 
• 834914-37-3 methyl 4-(hydroxymethyl)tetrahydro-2H-pyran-4-carboxylate 
• 5337-03-1 tetrahydro-2H-pyran-4-carboxylic acid 

Relevant articles and documents

Quinoline multi-target kinase inhibitor with antitumor activity and preparation method thereof

The invention relates to a quinoline multi-target kinase inhibitor with antitumor activity and a preparation method thereof. A general structural formula of the compound is shown in a formula (I) described in the specification. In vitro cell experiments verify that the compound provided by the invention has strong in vitro inhibitory activity on five common tumor cell lines, namely human thyroid carcinoma SW579, human hepatic carcinoma HepG2, human lung adenocarcinoma A549, human colorectal adenocarcinoma HCT116 and human gastric carcinoma MKN45, antitumor activities of most of target compounds are better than or equivalent to that of a positive control drug Cabozantinib, and the in vitro cell experiments verify that the compound provided by the invention has strong inhibitory activity on two kinases KDR and MET, so that the compound provided by the invention has a broad application prospect in preparation of a new antitumor drug.