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1476-78-4

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  • 1476-78-4 Structure

  • Basic information

    1. Product Name: 6alpha-Hydroxyestrone
    2. Synonyms: 6-hydroxyestrone;3,6α-Dihydroxy-1(10),2,4-estratriene-17-one;Estra-1,3,5(10)-trien-17-one, 3,6-dihydroxy-, (6alpha)-;(6α)-3,6-Dihydroxyestra-1,3,5(10)-trien-17-one;3,6α-Dihydroxyestra-1,3,5(10)-trien-17-one
    3. CAS NO:1476-78-4
    4. Molecular Formula: C18H22O3
    5. Molecular Weight: 0
    6. EINECS: N/A
    7. Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Steroids;Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
    8. Mol File: 1476-78-4.mol
    9. Article Data: 1

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 492.1°Cat760mmHg
    3. Flash Point: 265.5°C
    4. Appearance: /
    5. Density: 1.249g/cm3
    6. Vapor Pressure: 1.69E-10mmHg at 25°C
    7. Refractive Index: 1.611
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 6alpha-Hydroxyestrone(CAS DataBase Reference)
    11. NIST Chemistry Reference: 6alpha-Hydroxyestrone(1476-78-4)
    12. EPA Substance Registry System: 6alpha-Hydroxyestrone(1476-78-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1476-78-4(Hazardous Substances Data)

1476-78-4 Usage

Description

6alpha-Hydroxyestrone is a 6alpha-hydroxy steroid that is estrone substituted by an alpha-hydroxy group at position 6. It is an oxidative metabolite of 17β-Estradiol (E887995) and Estrone (E889050) formed by 15 selectively expressed human cytochrome P450 isoforms.

Uses

Used in Pharmaceutical Industry:
6alpha-Hydroxyestrone is used as a pharmaceutical compound for its potential role in modulating hormone levels and its involvement in the metabolism of estrogen. It may have applications in the development of treatments for hormone-related conditions and disorders.
Used in Research and Development:
6alpha-Hydroxyestrone is used as a research compound for studying the effects of estrogen metabolism on various physiological processes and the role of cytochrome P450 isoforms in the oxidative metabolism of estrogens.
Used in Drug Delivery Systems:
Similar to gallotannin, 6alpha-Hydroxyestrone could potentially be used in drug delivery systems to improve its bioavailability and therapeutic outcomes. This would require further research and development to explore the most effective methods for delivery and application in various medical conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 1476-78-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,7 and 6 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1476-78:
(6*1)+(5*4)+(4*7)+(3*6)+(2*7)+(1*8)=94
94 % 10 = 4
So 1476-78-4 is a valid CAS Registry Number.
InChI:InChI=1/C18H22O3/c1-18-7-6-12-11-3-2-10(19)8-14(11)16(20)9-13(12)15(18)4-5-17(18)21/h2-3,8,12-13,15-16,19-20H,4-7,9H2,1H3/t12-,13-,15+,16?,18+/m1/s1

1476-78-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 6α-hydroxyestrone

1.2 Other means of identification

Product number -
Other names 6alpha-hydroxyestrone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1476-78-4 SDS

1476-78-4Downstream Products

1476-78-4Relevant articles and documents

IDENTIFICATION OF 6α- AND 7α-HYDROXYESTRONE AS MAJOR METABOLITES OF ESTRONE AND ESTRADIOL IN PORCINE UTERUS

Maschler, I.,Ball, P.,Bayerkoehler, G.,Gaues, J.,Knuppen, R.

, p. 597 - 608 (2007/10/02)

Polar metabolites extracted from the effluents of viable porcine uterine strips superfused with either 6,7-3H-estrone or 6,7-3H-estradiol were identified as a 1 : 1 mixture of 6α-hydroxyestrone and 7α-hydroxyestrone by paper chromatography in various systems, derivatization and crystallizations to a constant specific activity.The hydroxylated compounds are the only derivatives detected after estrone superfusion.The major metabolite of estradiol released in short-time experiments is estrone followed by its 6α- and 7α-hydroxylated derivatives.

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