1474-30-2Relevant articles and documents
An efficient and mild synthesis of highly substituted imidazoles
Brackeen, Marcus F.,Stafford, Jeffrey A.,Feldman, Paul L.,Karanewsky, Donald S.
, p. 1635 - 1638 (1994)
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Versatile Route to Substituted Ketones through Charge-Directed Conjugate Addition Reactions
Cooke, Manning P.
, p. 4963 - 4968 (2007/10/02)
Charge-directed conjugate addition reactions have been applied to the preparation of highly substituted ketones.Acylphosphoranes resulting from conjugate addition-alkylation reactions are reduced by Al-Hg to β-keto esters, which, upon alkylation and hydrolysis, give ketones in high yields.An application of this methodology to the synthesis of 9, the defense substance of L. longipes, is described.