1473363-67-5

Basic information

• Product Name: C₁₄H₁₀N₂O₃
• CAS NO: 1473363-67-5
• Molecular Weight: 254.245
• Mol File: 1473363-67-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₄H₁₀N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₁₀N₂O₃(1473363-67-5)
• EPA Substance Registry System: C₁₄H₁₀N₂O₃(1473363-67-5)

Safety Data

• Hazardous Substances Data: 1473363-67-5(Hazardous Substances Data)

Upstream product

• 100-70-9 2-Cyanopyridine 
• 937-31-5 (4-Nitrophenyl)acetylene 

Relevant articles and documents

[bmim]OH promoted hydroalkynylation of nitrile and intramolecular hydroamination of the carbon-carbon multiple bond: An efficient and eco-compatible strategy for the synthesis of indolizinones

An efficient and novel hydroalkynylation of 2-cyanopyridine with arylacetylene and a subsequent intramolecular hydroamination promoted by a basic ionic-liquid, [bmim]OH, under microwave activation in the absence of an organic solvent and an inorganic base, yielding biodynamic indolizinones has been developed. The protocol involves [bmim]OH mediated in situ generation and addition of a nucleophilic alkynide from the aryl substituted terminal on a carbon alkyne of a polar nitrile group of 2-cyanopyridine. This results in the formation of a 2-pyridylphenylethynyl methimine intermediate which, on subsquent intramolecular nucleophilic addition of a pyridyl nitrogen on the carbon-carbon triple bond of the imine intermediate, heterocyclized into indolizinone with high atom economy. The reaction proceeded smoothly and quantitatively at an ambient temperature. The task specific [bmim]OH was recovered and reused three times without any appreciable decrease in its activity and product yield. The Royal Society of Chemistry 2013.