14631-44-8

Basic information

• Product Name: 3-FURANCARBONITRILE, TETRAHYDRO-
• Synonyms: 3-FURANCARBONITRILE, TETRAHYDRO-;3-Cyanotetrahydrofuran;3-Cyano-THF;tetrahydrofuran-3-carbonitrile;tetrahydro-3-furancarbonitrile(SALTDATA: FREE);Tetrahydro-3-furancarbonitrile;oxolane-3-carbonitrile
• CAS NO: 14631-44-8
• Molecular Formula: C₅H₇NO
• Molecular Weight: 97.11518
• Mol File: 14631-44-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 207.41 °C at 760 mmHg
• Flash Point: 84.339 °C
• Appearance: /
• Density: 1.043 g/cm³
• Vapor Pressure: 0.226mmHg at 25°C
• Refractive Index: 1.445
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-FURANCARBONITRILE, TETRAHYDRO-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FURANCARBONITRILE, TETRAHYDRO-(14631-44-8)
• EPA Substance Registry System: 3-FURANCARBONITRILE, TETRAHYDRO-(14631-44-8)

Safety Data

• Hazardous Substances Data: 14631-44-8(Hazardous Substances Data)

Usage

Chemical Properties

Colorless or light yellow liquid

InChI:InChI=1/C5H7NO/c6-3-5-1-2-7-4-5/h5H,1-2,4H2

Upstream product

• 871677-92-8 tetrahydrofuran-3-carboxamide 
• 75-21-8 oxirane 
• 107-13-1 acrylonitrile 
• 19311-38-7 3-chlorotetrahydrofuran 
• 773837-37-9 sodium cyanide 
• 1740-67-6 2-chloroethyl 2-cyanoethyl ether 
• 143-33-9 sodium cyanide 
• 156380-34-6 methanesulfonic acid tetrahydro-furan-3-yl ester 
• 151-50-8 potassium cyanide 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 13694-84-3 tetrahydro-3-furanyl tosylate 
• 136421-00-6 tetrahydrofuran-3-yl trifluoromethanesulfonate 

Downstream Products

• 165253-31-6 (tetrahydro-3-furanyl)methylamine 
• 1092544-69-8 N-(4-Fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-2-(tetrahydrofuran-3-yl)-1,6-dihydropyrimidine-4-carboxamide 
• 1092544-81-4 N-(4-fluoro-2-(3-(2-methoxyethyl)-2-oxoimidazolidin-1-yl)benzyl)-5-hydroxy-1-methyl-6-oxo-2-(tetrahydrofuran-3-yl)-1,6-dihydropyrimidine-4-carboxamide 
• 1092544-80-3 N-(4-fluoro-2-(3-methyl-2-oxoimidazolidin-1-yl)benzyl)-5-hydroxy-1-methyl-6-oxo-2-(tetrahydrofuran-3-yl)-1,6-dihydropyrimidine-4-carboxamide 
• 1092544-79-0 N-(4-fluoro-2-(4-methyl-4H-1,2,4-triazol-3-yl)benzyl)-5-hydroxy-1-methyl-6-oxo-2-(tetrahydrofuran-3-yl)-1,6-dihydropyrimidine-4-carboxamide 
• 1092544-74-5 N-(4-fluoro-2-(1-methyl-1H-1,2,4-triazol-5-yl)benzyl)-5-hydroxy-1-methyl-6-oxo-2-(tetrahydrofuran-3-yl)-1,6-dihydropyrimidine-4-carboxamide 
• 1092544-73-4 N-(4-fluoro-2-(5-methyl-1H-1,2,3-triazol-1-yl)benzyl)-5-hydroxy-1-methyl-6-oxo-2-(tetrahydrofuran-3-yl)-1,6-dihydropyrimidine-4-carboxamide 
• 1092544-72-3 N-(4-fluoro-2-(5-methyl-1H-1,2,4-triazol-1-yl)benzyl)-5-hydroxy-1-methyl-6-oxo-2-(tetrahydrofuran-3-yl)-1,6-dihydropyrimidine-4-carboxamide 
• 1092544-71-2 N-(4-fluoro-2-(1H-1,2,4-triazol-1-yl)benzyl)-5-hydroxy-1-methyl-6-oxo-2-(tetrahydrofuran-3-yl)-1,6-dihydropyrimidine-4-carboxamide 
• 1092544-77-8 N-(4-fluoro-2-(1,1-dioxo-1λ6-[1,2]thiazinan-2-yl)benzylcarbamoyl)-5-hydroxy-1-methyl-6-oxo-2-(tetrahydrofuran-3-yl)-1,6-dihydropyrimidine-4-carboxamide 
• 1092544-78-9 N-(2-(N,N-dimethylsulfamoyl)-4-fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-2-(tetrahydrofuran-3-yl)-1,6-dihydropyrimidine-4-carboxamide 
• 1092544-75-6 N-(4-fluoro-2-(methylsulfonyl)benzyl)-5-hydroxy-1-methyl-6-oxo-2-(tetrahydrofuran-3-yl)-1,6-dihydropyrimidine-4-carboxamide 
• 249760-25-6 C₁₀H₁₉NO₂ 
• 871677-92-8 tetrahydrofuran-3-carboxamide 

Relevant articles and documents

Synthesis method for 3-aminomethyl tetrahydrofuran

The invention provides a synthetic method for 3-aminomethyl tetrahydrofuran. A target product, namely the 3-aminomethyl tetrahydrofuran is prepared by taking 2,5-dihydrofuran as an initial raw material. In the whole synthesis process, the synthesis method has the advantages of green and environmentally-friendly used raw materials, mild and conveniently-controllable reaction conditions, safe production, low risk, simple process, high yield, and more applicability to industrial production.

Synthesis method of tetrahydrofuran-3-methylamine

The invention discloses a synthesis method of tetrahydrofuran-3-methylamine. The problems that the synthesis of the tetrahydrofuran-3-methylamine has the disadvantages of fussy route process, higher cost and harsh reaction condition in the prior art are solved. The synthesis method comprises the following steps of (1), in an organic solvent I, making acrylonitrile and epoxy ethane react to generate 3-cyano-tetrahydrofuran in a condition that a catalyst A exists; (2), purifying the 3-cyano-tetrahydrofuran, and then reducing the purified 3-cyano-tetrahydrofuran to obtain tetrahydrofuran-3-methylamine in conditions of an organic solvent II and a catalyst B. By using the synthesis method, the process flow and the production period are greatly shortened; raw materials are easily obtained; the synthesis method is green and environment-friendly, is low in cost, is simple to operate, is high in yield, and has obvious socioeconomic benefit and commercial application value.

Preparation method for 3-aminomethyltetrahydrofuran

The invention discloses a preparation method for 3-aminomethyltetrahydrofuran. The preparation method comprises the following steps: with acrylonitrile as a starting material, carrying out an addition reaction with 2-halogenated ethyl alcohol so as to obtain an intermediate 2-haloethyl-2-nitrile ethyl ether; then subjecting the intermediate 2-haloethyl-2-nitrile ethyl ether to cyclic condensation so as to obtain an intermediate 3-nitrile tetrahydrofuran; and finally subjecting the intermediate 3-nitrile tetrahydrofuran to catalytic hydrogenation so as to obtain 3-aminomethyltetrahydrofuran. The preparation method provided by the invention has the advantages of cheap and easily-available starting material, short synthetic route, simple process operation, low production cost, little pollution to the human body and the environment, good yield and applicability to large-scale industrial production.