144825-44-5 Usage
Description
3-Pyridinemethanol, alpha-ethenyl-(9CI), also known as 2-(4-Pyridyl)ethanol, is a chemical compound with the molecular formula C7H7NO. It is a derivative of pyridine, featuring a hydroxyl group and an ethenyl group attached to the pyridine ring. This colorless to pale yellow liquid exhibits a sweet odor and is soluble in water, ethanol, and ether. Due to its flammable nature and potential to cause irritation to the skin, eyes, and respiratory system, caution is advised during handling.
Uses
Used in Pharmaceutical Synthesis:
3-Pyridinemethanol, alpha-ethenyl-(9CI) is utilized as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to serve as a building block for the development of new drugs, particularly those targeting the central nervous system or having antimicrobial properties.
Used in Agrochemical Production:
In the agrochemical industry, 3-Pyridinemethanol, alpha-ethenyl-(9CI) is employed as a precursor in the production of pesticides and other crop protection agents. Its chemical properties make it suitable for the creation of compounds that can effectively manage pests and diseases in agriculture.
Used as a Solvent:
Due to its solubility in water, ethanol, and ether, 3-Pyridinemethanol, alpha-ethenyl-(9CI) can be used as a solvent in various chemical processes. This application takes advantage of its ability to dissolve a wide range of substances, facilitating reactions in research and industrial settings.
Used in Research:
3-Pyridinemethanol, alpha-ethenyl-(9CI) is also valuable in scientific research, particularly in the fields of organic chemistry and medicinal chemistry. It serves as a model compound for studying reactions and mechanisms involving pyridine derivatives, contributing to the advancement of chemical knowledge and the development of new compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 144825-44-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,8,2 and 5 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 144825-44:
(8*1)+(7*4)+(6*4)+(5*8)+(4*2)+(3*5)+(2*4)+(1*4)=135
135 % 10 = 5
So 144825-44-5 is a valid CAS Registry Number.
144825-44-5Relevant articles and documents
One-Pot Conversion of Allylic Alcohols to α-Methyl Ketones via Iron-Catalyzed Isomerization-Methylation
Latham, Daniel E.,Polidano, Kurt,Williams, Jonathan M. J.,Morrill, Louis C.
supporting information, p. 7914 - 7918 (2019/10/16)
A one-pot iron-catalyzed conversion of allylic alcohols to α-methyl ketones has been developed. This isomerization-methylation strategy utilized a (cyclopentadienone)iron(0) carbonyl complex as precatalyst and methanol as the C1 source. A diverse range of allylic alcohols undergoes isomerization-methylation to form α-methyl ketones in good isolated yields (up to 84% isolated yield).
Isothiourea-Catalysed Acylative Kinetic Resolution of Aryl–Alkenyl (sp2vs. sp2) Substituted Secondary Alcohols
Musolino, Stefania F.,Ojo, O. Stephen,Westwood, Nicholas J.,Taylor, James E.,Smith, Andrew D.
supporting information, p. 18916 - 18922 (2016/12/26)
The non-enzymatic acylative kinetic resolution of challenging aryl–alkenyl (sp2vs. sp2) substituted secondary alcohols is described, with effective enantiodiscrimination achieved using the isothiourea organocatalyst HyperBTM (1 mol %) and isobutyric anhydride. The kinetic resolution of a wide range of aryl–alkenyl substituted alcohols has been evaluated, with either electron-rich or naphthyl aryl substituents in combination with an unsubstituted vinyl substituent providing the highest selectivity (S=2–1980). The use of this protocol for the gram-scale (2.5 g) kinetic resolution of a model aryl–vinyl (sp2vs. sp2) substituted secondary alcohol is demonstrated, giving access to >1 g of each of the product enantiomers both in 99:1 e.r.
Tandem catalytic allylic amination and [2,3]-stevens rearrangement of tertiary amines
Soheili, Arash,Tambar, Uttam K.
supporting information; experimental part, p. 12956 - 12959 (2011/10/08)
We have developed a catalytic allylic amination involving tertiary aminoesters and allylcarbonates, which is the first example of the use of tertiary amines as intermolecular nucleophiles in metal-catalyzed allylic substitution chemistry. This process is
