144689-94-1Relevant articles and documents
An improved synthesis of 2-n-(propyl)-1H-imidazole-4,5-dicarboxylic acid diethyl ester
Wen, Xinmin,Yu, Xinhong,Tang, Jan
, p. 410 - 412 (2006)
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Preparation method of 2-propyl-4, 5-imidazole diethyl dicarboxylate
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Paragraph 0049; 0051, (2020/06/16)
The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of 2-propyl-4, 5-imidazole diethyl dicarboxylate, which comprises the following steps: by using L-tartaric acid as an initial raw material, carrying out esterification reaction, oxidation reaction and cyclization reaction to obtain the 2-propyl-4, 5-imidazole diethyl dicarboxylate product. A one-pot method is adopted for preparation, the method is simple, safety is good, and industrial production is easy to implement; the method has the advantages of mild reaction conditions, less three wastes, simple distillation and recycling of the solvent, simple process, low cost, high product purity and high yield compared with the existing process.
2-aminoalkylimidazole -4, 5-dicarboxilic manufacturing method
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Paragraph 0097, (2016/12/12)
PROBLEM TO BE SOLVED: To provide a method for producing inexpensively with a high yield, 2-alkylimidazole-4,5-dicarboxylic acid which is useful as a medicinal intermediate. SOLUTION: In this method for producing 2-alkylimidazole-4,5-dicarboxylic acid, tartaric acid is dissolved into nitric acid and then reacted with concentrated sulfuric acid, and a nitrate of tartaric acid acquired by the reaction is added into a solvent containing at least one kind of organic solvent selected from among N-methyl-2-pyrrolidone, dimethylformamide, dimethylacetamide, methylcyclohexane and toluene. Thereafter, a mixed liquid of aldehyde and ammonia is added to the reaction liquid, to thereby produce 2-alkylimidazole-4,5-dicarboxylic acid. COPYRIGHT: (C)2012,JPOandINPIT