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1444000-02-5

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1444000-02-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1444000-02-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,4,0,0 and 0 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1444000-02:
(9*1)+(8*4)+(7*4)+(6*4)+(5*0)+(4*0)+(3*0)+(2*0)+(1*2)=95
95 % 10 = 5
So 1444000-02-5 is a valid CAS Registry Number.

1444000-02-5Downstream Products

1444000-02-5Relevant articles and documents

In vitro biosynthesis, isolation, and identification of predominant metabolites of 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7- dimethoxyquinazolin-4(3H)-one (RVX-208)

Khmelnitsky, Yuri L.,Mozhaev, Vadim V.,Cotterill, Ian C.,Michels, Peter C.,Boudjabi, Sihem,Khlebnikov, Vladimir,Madhava Reddy,Wagner, Gregory S.,Hansen, Henrik C.

, p. 121 - 128 (2013/07/27)

The structures of the two predominant metabolites (M4 and M5) of RVX-208, observed both in in vitro human and animal liver microsomal incubations, as well as in plasma from animal in vivo studies, were determined. A panel of biocatalytic systems was tested to identify biocatalysts suitable for milligram scale production of metabolite M4 from RVX-208. Rabbit liver S9 fraction was selected as the most suitable system, primarily based on pragmatic metrics such as catalyst cost and estimated yield of M4 (~55%). Glucuronidation of RVX-208 catalyzed by rabbit liver S9 fraction was optimized to produce M4 in amounts sufficient for structural characterization. Structural studies using LC/MS/MS analysis and 1H NMR spectroscopy showed the formation of a glycosidic bond between the primary hydroxyl group of RVX-208 and glucuronic acid. NMR results suggested that the glycosidic bond has the β-anomeric configuration. A synthetic sample of M4 confirmed the proposed structure. Metabolite M5, hypothesized to be the carboxylate of RVX-208, was prepared using human liver microsomes, purified by HPLC, and characterized by LC/MS/MS and 1H NMR. The structure was confirmed by comparison to a synthetic sample. Both samples confirmed M5 as a product of oxidation of primary hydroxyl group of RVX-208 to carboxylic acid.

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