143632-83-1

Basic information

• Product Name: Benzamide, N-heptyl-
• CAS NO: 143632-83-1
• Molecular Formula: C14H21NO
• Molecular Weight: 219.327
• Mol File: 143632-83-1.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzamide, N-heptyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-heptyl-(143632-83-1)
• EPA Substance Registry System: Benzamide, N-heptyl-(143632-83-1)

Safety Data

• Hazardous Substances Data: 143632-83-1(Hazardous Substances Data)

Upstream product

• 5730-02-9 N-benzyl-1-heptylamine 
• 93-58-3 benzoic acid methyl ester 
• 111-68-2 1-Heptylamine 
• 98-88-4 benzoyl chloride 
• 90050-15-0 1-Aza-1-chlorooctane 
• 100-52-7 benzaldehyde 
• 44961-22-0 1-azidoheptane 
• 5908-41-8 benzoyltrimethylsilane 
• 63935-93-3 benzoyltriethylsilane 
• 132868-67-8 (tert-butyldimethylsilyl)(phenyl)methanone 
• 13411-45-5 trimethyl(2-phenyl-1,3-dithian-2-yl)silane 
• 461051-82-1 2-phenyl-2-triethylsilyl-1,3-dithiane 
• 461051-83-2 2-phenyl-2-(tert-butyl dimethylsilyl)-1,3-dithiane 
• 629-04-9 1-Bromoheptane 

Relevant articles and documents

Microwave-assisted synthesis of amides from various amines and benzoyl chloride under solvent-free conditions: A rapid and efficient method for selective protection of diverse amines

A number of structurally diverse amides were synthesized by reaction of the corresponding amines with benzoyl chloride under microwave irradiation. The proposed procedure ensures short reaction time, high yields, and excellent selectivity and considerably broadens the series of amines as compared to the microwave-assisted synthesis of amides directly from carboxylic acids. It can also be used for selective protection of various amines, including aromatic, aliphatic, and heterocyclic.

Near-Ambient-Temperature Dehydrogenative Synthesis of the Amide Bond: Mechanistic Insight and Applications

The current existing methods for the amide bond synthesis via acceptorless dehydrogenative coupling of amines and alcohols all require high reaction temperatures for effective catalysis, typically involving reflux in toluene, limiting their potential practical applications. Herein, we report a system for this reaction that proceeds under mild conditions (reflux in diethyl ether, boiling point 34.6 °C) using ruthenium PNNH complexes. The low-temperature activity stems from the ability of Ru-PNNH complexes to activate alcohol and hemiaminals at near-ambient temperatures through the assistance of the terminal N-H proton. Mechanistic studies reveal the presence of an unexpected aldehyde-bound ruthenium species during the reaction, which is also the catalytic resting state. We further utilize the low-temperature activity to synthesize several simple amide bond-containing commercially available pharmaceutical drugs from the corresponding amines and alcohols via the dehydrogenative coupling method.

Intermolecular Schmidt reaction of alkyl azides with acyl silanes

The first intermolecular Schmidt reaction of alkyl azides with acyl silanes has been designed and realized, producing a range of amides with absolute site selectivity in good to excellent yields. The mechanism of the conversion has been proposed, and the reaction exhibits scope of substrates.