143490-25-9

Basic information

• Product Name: Benzenamine, N-methyl-4-nitro-N-(trifluoromethyl)-
• CAS NO: 143490-25-9
• Molecular Formula: C8H7F3N2O2
• Molecular Weight: 220.151
• Mol File: 143490-25-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzenamine, N-methyl-4-nitro-N-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, N-methyl-4-nitro-N-(trifluoromethyl)-(143490-25-9)
• EPA Substance Registry System: Benzenamine, N-methyl-4-nitro-N-(trifluoromethyl)-(143490-25-9)

Safety Data

• Hazardous Substances Data: 143490-25-9(Hazardous Substances Data)

Upstream product

• 100-15-2 N-methyl(p-nitroaniline) 
• 143490-34-0 Methyl-(4-nitro-phenyl)-dithiocarbamic acid methyl ester 

Relevant articles and documents

One-pot synthesis of trifluoromethyl amines and perfluoroalkyl amines with CF3SO2Na and RfSO2Na

A newly developed CF3SO2Na-based trifluoromethylation of secondary amines has been disclosed, and the method has been successfully extended to the configuration of perfluoroalkyl amines using RfSO2Na, complementing the established synthesis strategy of trifluoromethyl amines. Advantages of the method include good functional group tolerance, mild conditions, and inexpensive or easy-to-handle materials. Mechanistic probes indicate that the thiocarbonyl fluoride formed in situ is the key intermediate in the reaction.

Reaction of Thiocarbonyl Fluoride Generated from Difluorocarbene with Amines

The reaction of thiocarbonyl fluoride, generated from difluorocarbene, with various amines under mild conditions is described. Secondary amines, primary amines, and o-phenylenediamines are converted to thiocarbamoyl fluorides, isothiocyanates, and difluoromethylthiolated heterocycles, respectively. Thiocarbamoyl fluorides were further transformed into trifluoromethylated amines by using a one-pot process. Thiocarbonyl fluoride is generated in situ and is rapidly fully converted in one pot under mild conditions; therefore, no special safety precautions are needed.

A Facile Synthesis of Trifluoromethylamines by Oxidative Desulfurization-Fluorination of Dithiocarbamates

Reaction of methyl dithiocarbamates R1R2N-C(S)SMe with n-Bu4N(1+)H2F3(1-) and N-bromosuccinimde provides trifluoromethylamines R1R2N-CF3 in good yields. Key Words: oxidative desulfurization-fluorination; dithiocarbamates; trifluoromethylamine