143415-63-8 Usage
Description
Boc-2-Methoxy-L-Phenylalanine is an unnatural amino acid derived from a C-H Activation methodology developed by Jin-Quan Yu and coworkers. It is synthesized through the Pd-mediated C-C bond formation in tandem with 2-Methylpyridine.
Uses
Used in Pharmaceutical Industry:
Boc-2-Methoxy-L-Phenylalanine is used as a building block for the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of novel drugs with potential applications in treating different medical conditions.
Used in Chemical Research:
Boc-2-Methoxy-L-Phenylalanine serves as an important intermediate in chemical research, particularly in the field of organic synthesis. It can be utilized to explore new reaction pathways and develop innovative synthetic methods.
Used in Material Science:
In the field of material science, Boc-2-Methoxy-L-Phenylalanine can be employed as a component in the development of advanced materials with specific properties, such as improved stability or enhanced biocompatibility.
Used in Peptide Synthesis:
Boc-2-Methoxy-L-Phenylalanine is used as a non-natural amino acid in peptide synthesis, allowing for the creation of novel peptide sequences with potential applications in drug discovery and development.
Check Digit Verification of cas no
The CAS Registry Mumber 143415-63-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,4,1 and 5 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 143415-63:
(8*1)+(7*4)+(6*3)+(5*4)+(4*1)+(3*5)+(2*6)+(1*3)=108
108 % 10 = 8
So 143415-63-8 is a valid CAS Registry Number.
143415-63-8Relevant articles and documents
Highly practical methodology for the synthesis of D- and L-α-amino acids, N-protected α-amino acids, and N-methyl-α-amino acids
Myers, Andrew G.,Gleason, James L.,Yoon, Taeyoung,Kung, Daniel W.
, p. 656 - 673 (2007/10/03)
Full details are provided for an exceedingly practical method to synthesize D- and L-α-amino acids, N-protected α-amino acids, and N-methyl-α-amino acids, employing as a key step the asymmetric alkylation of pseudoephedrine glycinamide (1) or pseudoephedrine sarcosinamide (2). Practical procedures for the synthesis of 1 and 2 from pseudoephedrine and glycine methyl ester or sarcosine methyl ester, respectively, are presented. Optimum protocols for the enolization and subsequent alkylation of 1 and 2 are described. Alkylation reactions of 1 and 2 are found to be quite efficient with a wide range of alkyl halide substrates, and the products are formed with high diastereoselectivity. The products of these alkylation reactions are hydrolyzed efficiently and with little to no racemization simply by heating in water or water-dioxane mixtures. This protocol provides an exceedingly practical method for the preparation of salt-free α-amino acids of high enantiomeric purity. Alternatively, the alkylation products may be hydrolyzed in high yield and with little to no racemization by heating with aqueous sodium hydroxide. The alkaline hydrolyzate can then be treated with an acylating reagent to provide directly highly enantiomerically enriched N-protected derivatives such as N-Boc and N-Fmoc. Key features necessary for the successful execution of these experimental procedures are identified.