143262-10-6 Usage
Description
1-BOC-INDOLINE, also known as tert-Butyl indoline-1-carboxylate, is an N-substituted indoline derivative. It is a versatile chemical compound that plays a significant role in various chemical reactions and synthesis processes.
Uses
1. Used in Pharmaceutical Industry:
1-BOC-INDOLINE is used as a reactant for the preparation of aryl alkyl amines through alkylation reactions catalyzed by Pd. This application is crucial in the synthesis of various pharmaceutical compounds.
2. Used in Chemical Synthesis:
1-BOC-INDOLINE serves as a reactant in the preparation of allyland arylindolines, which are essential building blocks in the synthesis of complex organic molecules.
3. Used in Modular Indole Synthesis:
In the field of organic chemistry, 1-BOC-INDOLINE is used as a reactant in the modular indole synthesis of the highly strained CDEF parent tetracycle of nodulisporic acids A and B. These compounds have potential applications in various industries, including pharmaceuticals and agrochemicals.
4. Used in Asymmetric Synthesis:
1-BOC-INDOLINE is employed as a reactant in the asymmetric synthesis of β-amino esters via rhodium prolinate complex-catalyzed α-C-H activation/carbenoid insertion reactions. This process is vital for the development of enantiomerically pure compounds, which are essential in the pharmaceutical industry.
5. Used in the Preparation of Substituted Indolines and Tetrahydroquinolines:
1-BOC-INDOLINE is utilized as a reactant in the preparation of substituted indolines and tetrahydroquinolines through a cycloaddition approach. These compounds are important intermediates in the synthesis of various biologically active molecules and pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 143262-10-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,2,6 and 2 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 143262-10:
(8*1)+(7*4)+(6*3)+(5*2)+(4*6)+(3*2)+(2*1)+(1*0)=96
96 % 10 = 6
So 143262-10-6 is a valid CAS Registry Number.
InChI:InChI=1/C13H17NO2/c1-13(2,3)16-12(15)14-9-8-10-6-4-5-7-11(10)14/h4-7H,8-9H2,1-3H3
143262-10-6Relevant articles and documents
Decarboxylative Intramolecular Arene Alkylation Using N-(Acyloxy)phthalimides, an Organic Photocatalyst, and Visible Light
Sherwood, Trevor C.,Xiao, Hai-Yun,Bhaskar, Roshan G.,Simmons, Eric M.,Zaretsky, Serge,Rauch, Martin P.,Knowles, Robert R.,Dhar, T. G. Murali
, p. 8360 - 8379 (2019/09/03)
An intramolecular arene alkylation reaction has been developed using the organic photocatalyst 4CzIPN, visible light, and N-(acyloxy)phthalimides as radical precursors. Reaction conditions were optimized via high-throughput experimentation, and electron-rich and electron-deficient arenes and heteroarenes are viable reaction substrates. This reaction enables access to a diverse set of fused, partially saturated cores which are of high interest in synthetic and medicinal chemistry.
Synthesis of indolines via a domino Cu-catalyzed amidation/cyclization reaction
Minatti, Ana,Buchwald, Stephen L.
scheme or table, p. 2721 - 2724 (2009/05/27)
(Chemical Equation Presented) A highly efficient one-pot procedure for the synthesis of indolines and their homologues based on a domino Cu-catalyzed amidation/nucleophilic substitution reaction has been developed. Substituted 2-iodophenethyl mesylates and related compounds afforded the corresponding products in excellent yields. No erosion of optical purity was observed when transforming enantiomerically pure mesylates under the reaction conditions.
Sulfonamide bicyclic compounds
-
Page/Page column 11, (2010/10/20)
The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts and solvates, their pharmaceutical compositions, and their uses in inhibiting β-amyloid peptide (β-AP) production.
