14273-90-6Relevant articles and documents
Synthesis of Tetradecapentaenoic Acid Derivatives
Kolodyazhnaya,Kolodyazhny
, p. 1998 - 2004 (2019)
A 12-stage method for the stereoselective synthesis of tetradecapentaenoic acid derivatives using phosphoric reagents was developed. The key step in the synthesis is the Z-selective Wittig reaction between sorbaldehyde and triphenylphosphonium (6-methoxycarbonyl)hexanilide, as well as the Ramirez-Corey-Fuchs reaction and the Trost-Kazmaier rearrangement. The synthesized (2E,4E,8Z,10E,12E)-N-isobutyltetradeca-2,4,8,10,12-pentaenamide corresponds to a natural compound called γ-Sansho?l.
Supramolecular assemblies from amphiphilic homopolymers: Testing the scope
Savariar, Elamprakash N.,Aathimanikandan, Sivakumar V.,Thayumanavan
, p. 16224 - 16230 (2006)
It has been shown by us in a recent communication that homopolymers, in which each repeat unit contains a hydrophilic and a hydrophobic head group, are capable of forming environment-dependent micellar or inverse micellar assemblies. A systematic structure-property relationship study is carried out here to test the scope of the design. We show here that the molecular design is indeed broadly applicable and that there is a significant gain in the critical aggregation concentrations of these polymers, as compared to the small molecule counterparts. We also show that the design can be tuned to achieve vesicle-type assemblies, which further expands the repertoire of amphiphilic homopolymers in a variety of areas. Characterizations of these assemblies have been carried out using transmission electron microscopy, dynamic light scattering, static light scattering, and dye incorporation experiments.
New Synthesis of Methyl 7-Oxoheptanoate: An Useful Intermediate for the Preparation of 2-(6-Methoxycarbonylhexyl)-cyclopent-2-en-1-one
Bosone, Enrico,Farina, Paolo,Guazzi, Guiseppe,Innocenti, Sergio,Marrotta, Vittorio,Valcavi, Umberto
, p. 942 - 944 (1983)
-
-
Schore,N.E.,Turro,N.J.
, p. 2488 - 2496 (1975)
-
-
Petraganani,N. et al.
, p. 112 - 113 (1977)
-
A modular approach toward block copolymers
Higley, Mary Nell,Pollino, Joel M.,Hollembeak, Eric,Weck, Marcus
, p. 2946 - 2953 (2005)
A novel methodology for the formation of block copolymers has been developed that combines ring- opening metathesis polymerization (ROMP) with functional chain-transfer agents (CTAs) and self-assembly. Telechelic homopolymers of cyclooctene derivatives en
Coordination-Mediated Synthesis of Purification-Free Bivalent 99mTc-Labeled Probes for in Vivo Imaging of Saturable System
Taira, Yuichiro,Uehara, Tomoya,Tsuchiya, Masao,Takemori, Hideaki,Mizuno, Yuki,Takahashi, Shiori,Suzuki, Hiroyuki,Hanaoka, Hirofumi,Akizawa, Hiromichi,Arano, Yasushi
, p. 459 - 466 (2018)
In the synthesis of technetium-99m (99mTc) labeled target-specific ligands, the presence of a large excess of unlabeled ligands over 99mTc in the injectate hinders target accumulation of 99mTc-labeled ligands by competing for target molecules. To circumvent the problem, we recently developed a concept of the metal coordination-mediated multivalency, and proved the concept with a 99mTc-labeled trivalent compound [99mTc(CO)3(CN-RGD)3]+. In this study, D-penicillamine (Pen) was selected as a chelating molecule and a cyclic RGDfK peptide was conjugated to Pen via a hexanoic linkage (Pen-Ahx-c(RGDfK)). 99mTc complexation reaction, and the stability, integrin αvβ3 binding affinity, and biodistribution of the 99mTc-labeled probe were investigated to evaluate the applicability of the concept to bivalent probes. 99mTc-[Pen-Ahx-c(RGDfK)]2 was obtained over 95% radiochemical yields under low Pen-Ahx-c(RGDfK) concentration (50 μM). 99mTc-[Pen-Ahx-c(RGDfK)]2 showed approximately 10-times higher integrin αvβ3 binding affinity than the monovalent compounds, Pen-Ahx-c(RGDfK) and c(RGDyV). In biodistribution studies, the tumor accumulation of 99mTc-[Pen-Ahx-c(RGDfK)]2 was decreased to 77% and 43% of HPLC-purified (Pen-Ahx-c(RGDfK)-free) 99mTc-[Pen-Ahx-c(RGDfK)]2 by the presence of 5 nmol of unlabeled Pen-Ahx-c(RGDfK) and Re-[Pen-Ahx-c(RGDfK)]2, respectively. 99mTc-[Pen-Ahx-c(RGDfK)]2 provided tumor image without removing unlabeled ligand, while a 99mTc-labeled monovalent probe prepared from a monovalent ligand could not. These findings indicate the availability of the design concept to prepare 99mTc-labeled bivalent probes with a variety of 99mTc core and other metallic radionuclides of clinical relevance.
AZACYANINE DYES AND USE THEREOF
-
Page/Page column 105, (2019/10/15)
The application provides fluorescent dyes, which are cyanine dyes that incorporate additional aza moieties in the indolenium heterocycles and/or in the methine chains connecting them. Symmetrical and unsymmetrical chemically reactive azacyanine dyes are described for conjugation, as well as their bioconjugates for in-vitro and in-vivo assays and fluorescence imaging.
AZACYANINE DYES AND USE THEREOF
-
Paragraph 0428-0429, (2018/04/13)
The application provides fluorescent dyes, which are cyanine dyes that incorporate additional aza moieties in the indolenium heterocycles and/or in the methine chains connecting them. Symmetrical and unsymmetrical chemically reactive azacyanine dyes are described for conjugation, as well as their bioconjugates for in-vitro and in-vivo assays and fluorescence imaging.
