1420071-30-2

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]-
• Synonyms: 1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]-;BioyMifi;(E)-5-(5-((3-(4-bromophenyl)-2-imino-4-oxothiazolidin-5-ylidene)methyl)furan-2-yl)isoindoline-1,3-dione;Bioymifi 1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]-;Bioymifi, 1420071-30-2;(Z)-5-(5-[(3-[4-Bromophenyl]-2-imino-4-oxothiazolidin-5-ylidene)methyl]furan-2-yl)isoindoline-1,3-dione;5-[5-[[(5Z)-3-(4-Bromophenyl)-2-imino-4-oxo-5-thiazolidinylidene]methyl]-2-furanyl]-1H-isoindole-1,3(2H)-dione;(Z)-5-(5-((3-(4-bromophenyl)-2-imino-4-oxothiazolidin-5-ylidene)methyl)furan-2-yl)isoindoline-1,3-dione (Bioymifi)
• CAS NO: 1420071-30-2
• Molecular Formula: C22H12BrN3O4S
• Molecular Weight: 494.31738
• Product Categories: Inhibitors
• Mol File: 1420071-30-2.mol
• Article Data: 0

Chemical Properties

• Appearance: , orange to dark orange red/
• Storage Temp.: 2-8°C
• Solubility: DMSO: soluble2mg/mL, clear (warmed)
• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]-(1420071-30-2)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]-(1420071-30-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 1420071-30-2(Hazardous Substances Data)

Usage

Description

1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]-, also known as Bioymifi, is a thiazolidinone derivative that plays a significant role in inducing apoptosis in various cancer cells. It functions as a TRAIL receptor DR5 binding agent, directly activating DR5 and initiating a cascade of events that lead to apoptosis. 1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]has shown potential in targeting human cancer cells and could be a promising candidate for further pharmaceutical development.

Uses

Used in Pharmaceutical Industry:
1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]is used as an apoptosis-inducing agent for the treatment of various types of cancer. Its mechanism of action involves directly activating the TRAIL receptor DR5 (Kd = 1.2 μM; IC50 = 2 μM), which leads to DR5 clustering and the initiation of FADD/caspase-8-dependent apoptosis in cancer cells. 1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]has demonstrated potential in targeting human cancer cells, making it a valuable asset in the development of novel cancer therapies.
Additionally, Bioymifi could be further explored for its potential synergistic effects when combined with conventional chemotherapeutic drugs, potentially enhancing chemo-sensitivity and efficacy in resistant cases. This aspect of its application could be particularly relevant in the field of cancer research and treatment, where overcoming drug resistance is a significant challenge.
Furthermore, the development of novel drug delivery systems for Bioymifi could be an area of focus to enhance its applications and efficacy against cancer cells. Utilizing various organic and metallic nanoparticles as carriers for Bioymifi delivery could improve its delivery, bioavailability, and therapeutic outcomes, making it a more effective treatment option for cancer patients.