1415356-21-6

Basic information

• Product Name: C₁₉H₁₇ClN₂O₃
• CAS NO: 1415356-21-6
• Molecular Weight: 356.809
• Mol File: 1415356-21-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₁₇ClN₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₁₇ClN₂O₃(1415356-21-6)
• EPA Substance Registry System: C₁₉H₁₇ClN₂O₃(1415356-21-6)

Safety Data

• Hazardous Substances Data: 1415356-21-6(Hazardous Substances Data)

Upstream product

• 1035450-70-4 4,5-dichloro-2-(3,4-dimethylphenyl)pyridazin-3(2H)-one 
• 150-76-5 4-methoxy-phenol 
• 13636-53-8 3,4-dimethylphenylhydrazine 

Relevant articles and documents

Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)

Novel small molecule antagonists of NPBWR1 (GPR7) are herein reported. A high-throughput screening (HTS) of the Molecular Libraries-Small Molecule Repository library identified 5-chloro-4-(4-methoxyphenoxy)-2-(p-tolyl) pyridazin-3(2H)-one as a NPBWR1 hit antagonist with micromolar activity. Design, synthesis and structure-activity relationships study of the HTS-derived hit led to the identification of 5-chloro-2-(3,5-dimethylphenyl)-4-(4-methoxyphenoxy) pyridazin-3(2H)-one lead molecule with submicromolar antagonist activity at the target receptor and high selectivity against a panel of therapeutically relevant off-target proteins. This lead molecule may provide a pharmacological tool to clarify the molecular basis of the in vivo physiological function and therapeutic utility of NPBWR1 in diverse disease areas including inflammatory pain and eating disorders.