1407513-29-4Relevant articles and documents
Regioselective 6-endo-dig iodocyclization: An accessible approach for iodo-benzo [a] phenazines
Kumar, Sonu,Mujahid, Mohammad,Verma, Akhilesh K.
, p. 4686 - 4696 (2017/07/10)
A facile approach for the synthesis of substituted iodo-benzo[a]phenazines from 2-aryl-3-(aryl/alkylethynyl)quinoxalines via 6-endo-dig ring closure has been described under mild reaction conditions. Iodocyclization proceeds through the iodonium ion intermediate followed by nucleophilic cyclization with the C-H bond of the arene. Furthermore, the resulting 6-iodo-5-aryl/alkyl benzo[a]phenazine derivatives allowed for structural diversification by employing various coupling reactions. The structure of iodo-benzo[a]phenazine was confirmed by X-ray crystallographic studies of the compound.
Transition metal free hydrolysis/cyclization strategy in a single pot: Synthesis of fused furo N-heterocycles of pharmacological interest
Nakhi, Ali,Rahman, Md. Shafiqur,Seerapu, Guru Pavan Kumar,Banote, Rakesh Kumar,Kumar, Kummari Lalith,Kulkarni, Pushkar,Haldar, Devyani,Pal, Manojit
supporting information, p. 4930 - 4934 (2013/08/23)
A transition metal free tandem two-step strategy has been developed involving hydrolysis of 2-chloro-3-alkynyl quinoxalines/pyrazines followed by in situ cyclization of the corresponding 2-hydroxy-3-alkynyl intermediates in a single pot leading to fused furo N-heterocycles as potential inhibitors of sirtuins. A representative compound showed promising pharmacological properties in vitro and in vivo.
AlCl3-mediated hydroarylation-heteroarylation in a single pot: A direct access to densely functionalized olefins of pharmacological interest
Nakhi, Ali,Archana, Sivakumar,Seerapu, Guru Pavan Kumar,Chennubhotla, Keerthana Sarma,Kumar, Kummari Lalith,Kulkarni, Pushkar,Haldar, Devyani,Pal, Manojit
, p. 6268 - 6270 (2013/08/23)
An unprecedented AlCl3-mediated method has been developed involving aromatic C-H bond addition to an alkyne and heteroarylation of an arene in a single pot leading to densely functionalized novel olefins, e.g. 2-(2,2-diarylvinyl)-3-arylquinoxalines, as potential inhibitors of sirtuins.