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140-80-7 Usage

Description

2-Amino-5-diethylaminopentane, also known as pentylamine, is an organic compound with the molecular formula C7H17N. It is a colorless liquid that is toxic by ingestion, inhalation, and skin absorption. It is also irritating to the skin and eyes. 2-Amino-5-diethylaminopentane is primarily used to manufacture other chemicals, including quinacrine and other antimalarials with the same basic side chain.

Uses

Used in Pharmaceutical Industry:
2-Amino-5-diethylaminopentane is used as a chemical intermediate for the synthesis of various pharmaceutical compounds, such as quinacrine and other antimalarials. These antimalarial drugs are essential in treating and preventing malaria, a life-threatening disease caused by parasites transmitted through the bite of infected mosquitoes.
Used in Chemical Synthesis:
2-Amino-5-diethylaminopentane is used as a building block in the chemical synthesis of various organic compounds. Its unique structure allows it to be a versatile component in the creation of different molecules with potential applications in various industries.
Chemical Properties:
2-Amino-5-diethylaminopentane is a colorless liquid that is soluble in water and alcohol. Its chemical properties make it suitable for use in various chemical reactions and processes, contributing to its wide range of applications in the pharmaceutical and chemical industries.

Reactivity Profile

2-Amino-5-diethylaminopentane neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Check Digit Verification of cas no

The CAS Registry Mumber 140-80-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 0 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 140-80:
(5*1)+(4*4)+(3*0)+(2*8)+(1*0)=37
37 % 10 = 7
So 140-80-7 is a valid CAS Registry Number.
InChI:InChI=1/2C19H20FNO3.2ClH.H2O/c2*20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;;;/h2*1-6,9,14,17,21H,7-8,10-12H2;2*1H;1H2/t2*14-,17-;;;/m00.../s1

140-80-7 Well-known Company Product Price

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  • Aldrich

  • (A48806)  2-Amino-5-diethylaminopentane  97%

  • 140-80-7

  • A48806-25G

  • 418.86CNY

  • Detail

140-80-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Amino-5-diethylaminopentane

1.2 Other means of identification

Product number -
Other names N,N-diethyl-4-aminopentylamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:140-80-7 SDS

140-80-7Synthetic route

(R)-(-)-4-amino-1-(diethylamino)pentane
67459-50-1

(R)-(-)-4-amino-1-(diethylamino)pentane

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

Conditions
ConditionsYield
With nickel In toluene at 70℃; for 12h;97.2%
5-diethylaminopentan-2-ol
5412-69-1

5-diethylaminopentan-2-ol

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

Conditions
ConditionsYield
With ammonia; nickel at 200℃; unter Druck;
With ammonia; nickel at 200℃; unter Druck;
diethyl-(4-chloro-pentyl)-amine
39749-10-5

diethyl-(4-chloro-pentyl)-amine

A

N1,N1-diethyl-1-methyl-butanediyldiamine
344325-82-2

N1,N1-diethyl-1-methyl-butanediyldiamine

B

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

Conditions
ConditionsYield
With potassium phthalide; xylene at 150 - 160℃; anschl. Erwaermen mit HCl;
5-diethylamino-2-pentanone
105-14-6

5-diethylamino-2-pentanone

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

Conditions
ConditionsYield
With methanol; ammonia; nickel at 95 - 96℃; under 36775.4 Torr; Hydrogenation;
With ethanol; ammonia at 40℃;
Multi-step reaction with 2 steps
1: ethanol; Raney nickel; NH3 / Hydrogenation
2: methanol; nickel catalyst; hydrogen; NH3 / 14710.2 Torr
View Scheme
With methanol; ammonia; nickel at 70 - 80℃; Hydrogenation.unter Druck;
5-diethylamino-2-pentanone
105-14-6

5-diethylamino-2-pentanone

A

bis-(4-diethylamino-1-methyl-butyl)-amine
101881-56-5

bis-(4-diethylamino-1-methyl-butyl)-amine

B

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

Conditions
ConditionsYield
With ethanol; ammonia at 20℃;
With ethanol; ammonia; nickel Hydrogenation;
5-diethylamino-pentan-2-one oxime
5426-96-0

5-diethylamino-pentan-2-one oxime

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

Conditions
ConditionsYield
With ethanol; sodium
bis-(4-diethylamino-1-methyl-butyl)-amine
101881-56-5

bis-(4-diethylamino-1-methyl-butyl)-amine

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

Conditions
ConditionsYield
With methanol; ammonia; hydrogen; nickel under 14710.2 Torr;
hydrogenchloride
7647-01-0

hydrogenchloride

pamaquine
491-92-9

pamaquine

water
7732-18-5

water

NaNO2

NaNO2

A

6-methoxy-quinolin-8-ol
477601-28-8

6-methoxy-quinolin-8-ol

B

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

Conditions
ConditionsYield
anschl. mit methanol. KOH;
methanol
67-56-1

methanol

bis-(4-diethylamino-1-methyl-butyl)-amine
101881-56-5

bis-(4-diethylamino-1-methyl-butyl)-amine

ammonia
7664-41-7

ammonia

hydrogen

hydrogen

nickel catalyst

nickel catalyst

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

Conditions
ConditionsYield
under 14710.2 Torr;
5-diethylamino-2-pentanone
105-14-6

5-diethylamino-2-pentanone

ammonia
7664-41-7

ammonia

nickel

nickel

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

Conditions
ConditionsYield
Hydrogenation;
5-diethylamino-2-pentanone
105-14-6

5-diethylamino-2-pentanone

methanol.NH3

methanol.NH3

nickel

nickel

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

Conditions
ConditionsYield
Hydrogenation;
(4-diethylamino-1-methyl-butyl)-dithiocarbamic acid
18997-67-6

(4-diethylamino-1-methyl-butyl)-dithiocarbamic acid

A

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

B

CS2

CS2

Conditions
ConditionsYield
durch Saeuren;
durch Saeuren;
2-(diethylamino)acetaldehyde
32314-21-9

2-(diethylamino)acetaldehyde

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: alkaline solution
2: Raney nickel / Hydrogenation
3: ethanol; NH3 / 40 °C
View Scheme
5-diethylamino-pent-3-en-2-one
136571-69-2

5-diethylamino-pent-3-en-2-one

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Raney nickel / Hydrogenation
2: ethanol; NH3 / 40 °C
View Scheme
C9H22N2*C8H8O3

C9H22N2*C8H8O3

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / water / pH 11 - 12
2: nickel / toluene / 12 h / 70 °C
View Scheme
11-chloro-5-methyl-5H-indolo[2,3-b]quinoline
1150313-28-2

11-chloro-5-methyl-5H-indolo[2,3-b]quinoline

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

N1,N1-diethyl-N4-(5-methyl-5H-indolo[2,3-b]quinolin-11-yl)pentane-1,4-diamine
1150313-32-8

N1,N1-diethyl-N4-(5-methyl-5H-indolo[2,3-b]quinolin-11-yl)pentane-1,4-diamine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 135 - 155℃;99%
Heating;98%
at 80 - 120℃;98%
at 135 - 155℃; Neat (no solvent);77%
3-(1-hydroxyhexylidene)-5-(2-(methylthio)ethyl)-1-(3,5,5-trimethylhexanoyl)pyrrolidine-2,4-dione

3-(1-hydroxyhexylidene)-5-(2-(methylthio)ethyl)-1-(3,5,5-trimethylhexanoyl)pyrrolidine-2,4-dione

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

C31H57N3O3S

C31H57N3O3S

Conditions
ConditionsYield
In toluene Reflux;99%
1-benzoyl-3-(1-hydroxy-4-phenoxybutylidene)-5-isobutylpyrrolidine-2,4-dione

1-benzoyl-3-(1-hydroxy-4-phenoxybutylidene)-5-isobutylpyrrolidine-2,4-dione

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

C34H47N3O4

C34H47N3O4

Conditions
ConditionsYield
In toluene Reflux;99%
2-chloro-4-hydroxy-quinazoline
607-69-2

2-chloro-4-hydroxy-quinazoline

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

2-<<4-(diethylamino)-1-methylbutyl>amino>-4-quinazolinol
76005-48-6

2-<<4-(diethylamino)-1-methylbutyl>amino>-4-quinazolinol

Conditions
ConditionsYield
In ethanol for 14h; Heating;97%
perylene-3,4,9,10-tetracarboxylic acid 3,4:9,10-dianhydride
128-69-8

perylene-3,4,9,10-tetracarboxylic acid 3,4:9,10-dianhydride

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

N,N'-bis(4-diethylamino-1-methylbutyl)perylene-3,4:9,10-tetracarboxylic acid bisimide
106409-01-2

N,N'-bis(4-diethylamino-1-methylbutyl)perylene-3,4:9,10-tetracarboxylic acid bisimide

Conditions
ConditionsYield
With 1H-imidazole at 160℃; for 16h;97%
5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

8-amino-4,6-dichloroquinoline
181189-00-4

8-amino-4,6-dichloroquinoline

8-amino-6-chloro-4-(4-diethylamino-1-methylbutyl)aminoquinoline
181189-01-5

8-amino-6-chloro-4-(4-diethylamino-1-methylbutyl)aminoquinoline

Conditions
ConditionsYield
at 180℃; for 16h;96%
1-[7-chloro-4-(dimethylamino)quinolin-3-yl]-2,2,2-trifluoroethan-1-one
501947-42-8

1-[7-chloro-4-(dimethylamino)quinolin-3-yl]-2,2,2-trifluoroethan-1-one

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

1-[7-chloro-4-(5-diethylaminopentan-2-ylamino)quinolin-3-yl]-2,2,2-trifluoroethan-1-one

1-[7-chloro-4-(5-diethylaminopentan-2-ylamino)quinolin-3-yl]-2,2,2-trifluoroethan-1-one

Conditions
ConditionsYield
In acetonitrile for 8h; Reflux;95%
2-azidobenzaldehyde
16714-25-3

2-azidobenzaldehyde

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

C16H25N3

C16H25N3

Conditions
ConditionsYield
at 100℃; under 10343.2 Torr; Microwave irradiation;95%
(S)-Mandelic acid
17199-29-0

(S)-Mandelic acid

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

C9H22N2*C8H8O3

C9H22N2*C8H8O3

Conditions
ConditionsYield
In isopropyl alcohol at 20℃;94.9%
(R)-Mandelic Acid
611-71-2

(R)-Mandelic Acid

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

C9H22N2*C8H8O3

C9H22N2*C8H8O3

Conditions
ConditionsYield
In isopropyl alcohol at 20℃; for 3h;94.9%
In isopropyl alcohol at 20℃; for 3h;94.9%
4,7-dichloroquinoline
86-98-6

4,7-dichloroquinoline

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

Chloroquine
54-05-7

Chloroquine

Conditions
ConditionsYield
With diethylamine; phenol at 90 - 100℃; under 1140.08 Torr; Temperature; Reagent/catalyst; Pressure;90.72%
With indium(III) chloride In acetonitrile at 120℃; for 1h; Microwave irradiation; regioselective reaction;73%
1.) 100 deg C, 2 h, 2.) 150-160 deg C, 5 h;
at 135 - 140℃; for 24h;
With N-ethyl-N,N-diisopropylamine; sodium sulfite In isopropyl alcohol at 133 - 138℃; for 10h;137.5 g
5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

4-bromoquinoline
3964-04-3

4-bromoquinoline

4-(4-diethylamino-1-methylbutylamino)-quinoline
1915-92-0

4-(4-diethylamino-1-methylbutylamino)-quinoline

Conditions
ConditionsYield
With potassium phosphate; bis[2-(diphenylphosphino)phenyl] ether; palladium diacetate In 1,4-dioxane at 85℃; for 18h;88%
5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

formic acid ethyl ester
109-94-4

formic acid ethyl ester

N,N-diethyl-4-isocyanopentan-1-amine

N,N-diethyl-4-isocyanopentan-1-amine

Conditions
ConditionsYield
Stage #1: 5-diethylamino-2-pentylamine; formic acid ethyl ester for 16h; Reflux;
Stage #2: With bis(trichloromethyl) carbonate; N-ethyl-N,N-diisopropylamine In dichloromethane at -40 - 0℃; for 2h;
88%
3-hydroxy-2-methylene-3-(2-nitrophenyl)propanoic acid methyl ester
159763-36-7

3-hydroxy-2-methylene-3-(2-nitrophenyl)propanoic acid methyl ester

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

methyl 2-[(4-diethylamino-1-methylbutyl)amino-methy]-3-hydroxy-3-(2-nitrophenyl)propanoate

methyl 2-[(4-diethylamino-1-methylbutyl)amino-methy]-3-hydroxy-3-(2-nitrophenyl)propanoate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 48h;87%
5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

4-chloro-2-methylquinoline-6-carboxylic acid
181189-02-6

4-chloro-2-methylquinoline-6-carboxylic acid

4-(4-diethylamino-1-methylbutyl)amino-2-methylquinoline-6-carboxylic acid
181189-03-7

4-(4-diethylamino-1-methylbutyl)amino-2-methylquinoline-6-carboxylic acid

Conditions
ConditionsYield
at 150℃; for 5.5h;86%
4,8-dichloroquinoline
21617-12-9

4,8-dichloroquinoline

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

N4-(8-chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine
32668-65-8

N4-(8-chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine

Conditions
ConditionsYield
1.) 100 deg C, 2 h, 2.) 140-150 deg C, 7 h;85%
at 170℃;
1,11-dichloro-5-methyl-5H-indolo[2,3-b]quinoline
1150313-29-3

1,11-dichloro-5-methyl-5H-indolo[2,3-b]quinoline

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

N4-(1-chloro-5-methyl-5H-indolo[2,3-b]quinolin-11-yl)-N1,N1-diethyl-pentane-1,4-diamine
1150313-33-9

N4-(1-chloro-5-methyl-5H-indolo[2,3-b]quinolin-11-yl)-N1,N1-diethyl-pentane-1,4-diamine

Conditions
ConditionsYield
at 135 - 155℃; Neat (no solvent);85%
11-Chlor-5,10-dimethyl-10H-indolo<3,2-b>chinolinium-chlorid

11-Chlor-5,10-dimethyl-10H-indolo<3,2-b>chinolinium-chlorid

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

(R,S)-11-(4-Diethylamino-2-pentyl)-amino-5,10-dimethyl-10H-indolo<3,2-b>chinolinium-chlorid-hydrochlorid

(R,S)-11-(4-Diethylamino-2-pentyl)-amino-5,10-dimethyl-10H-indolo<3,2-b>chinolinium-chlorid-hydrochlorid

Conditions
ConditionsYield
In ethanol at 70℃; for 4h;84%
11-chloro-2-methoxychromeno[2,3-b]indole
1416412-79-7

11-chloro-2-methoxychromeno[2,3-b]indole

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

C25H31N3O2
1453096-24-6

C25H31N3O2

Conditions
ConditionsYield
at 80℃;84%
C25H35NO6
1603109-75-6

C25H35NO6

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

C34H55N3O5
1603109-04-1

C34H55N3O5

Conditions
ConditionsYield
In toluene Reflux;84%
5-(benzyloxy)-4-chloro-6-methoxyquinazoline
120075-53-8

5-(benzyloxy)-4-chloro-6-methoxyquinazoline

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

N4-(5-Benzyloxy-6-methoxy-quinazolin-4-yl)-N1,N1-diethyl-pentane-1,4-diamine
120075-68-5

N4-(5-Benzyloxy-6-methoxy-quinazolin-4-yl)-N1,N1-diethyl-pentane-1,4-diamine

Conditions
ConditionsYield
With triethylamine In ethanol for 24h; Ambient temperature;83%
7-chloro-5-methyl-2-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine
885461-50-7

7-chloro-5-methyl-2-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

C16H25F3N6

C16H25F3N6

Conditions
ConditionsYield
In ethanol at 20℃; for 43h;83%
C23H19N5O3S

C23H19N5O3S

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

(4″RS,2‴RS)-5-[3-(6-Amino-5-cyano-3-methyl-4-isopropyl-2,4-dihydropyrano[2,3-c]pyrazol-4-yl)-5-cyanophenyl]-N-[5-(diethylamino)pent-2-yl]thiophene-2-carboxamide

(4″RS,2‴RS)-5-[3-(6-Amino-5-cyano-3-methyl-4-isopropyl-2,4-dihydropyrano[2,3-c]pyrazol-4-yl)-5-cyanophenyl]-N-[5-(diethylamino)pent-2-yl]thiophene-2-carboxamide

Conditions
ConditionsYield
With 1,1'-carbonyldiimidazole In tetrahydrofuran at 25℃; for 0.5h;83%
1-(β-carboxyethyl)-1,2,3,4-tetrahydroquinoline
91641-02-0

1-(β-carboxyethyl)-1,2,3,4-tetrahydroquinoline

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

N-(5-(diethylamino)pentan-2-yl)-3-(3,4-dihydroquinolin-1(2H)-yl)propanamide

N-(5-(diethylamino)pentan-2-yl)-3-(3,4-dihydroquinolin-1(2H)-yl)propanamide

Conditions
ConditionsYield
Stage #1: 1-(β-carboxyethyl)-1,2,3,4-tetrahydroquinoline With O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 5-diethylamino-2-pentylamine In N,N-dimethyl-formamide at 20℃; for 1h;
82.5%
3,11-dichloro-6H-indolo[2,3-b]quinoline
1150313-26-0

3,11-dichloro-6H-indolo[2,3-b]quinoline

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

N4-(3-chloro-6H-indolo[2,3-b]quinolin-11-yl)-N1,N1-diethyl-pentane-1,4-diamine
1150313-44-2

N4-(3-chloro-6H-indolo[2,3-b]quinolin-11-yl)-N1,N1-diethyl-pentane-1,4-diamine

Conditions
ConditionsYield
at 20 - 155℃; for 13h;82%
2-bromo-11-chloro-5-methyl-5H-indolo[2,3-b]quinoline
1356825-65-4

2-bromo-11-chloro-5-methyl-5H-indolo[2,3-b]quinoline

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

N4-(2-bromo-5-methyl-5H-indolo[2,3-b]quinolin-11-yl)-N1,N1-diethylpentane-1,4-diamine
1393344-27-8

N4-(2-bromo-5-methyl-5H-indolo[2,3-b]quinolin-11-yl)-N1,N1-diethylpentane-1,4-diamine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 135 - 155℃;82%
Heating;64%
2,11-dichlorochromeno[2,3-b]indole
1416412-74-2

2,11-dichlorochromeno[2,3-b]indole

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

C24H28ClN3O
1453096-22-4

C24H28ClN3O

Conditions
ConditionsYield
at 80℃;82%
C11H9Cl2N
1536007-04-1

C11H9Cl2N

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

N4-(7-chloro-2-ethylquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine
1536007-16-5

N4-(7-chloro-2-ethylquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine

Conditions
ConditionsYield
With samarium(III) trifluoromethanesulfonate at 140℃; for 48h; Inert atmosphere;82%
2‑(methanesulfonyl)‑4‑methyl‑6‑(4‑methylphenyl)pyrimidine

2‑(methanesulfonyl)‑4‑methyl‑6‑(4‑methylphenyl)pyrimidine

5-diethylamino-2-pentylamine
140-80-7

5-diethylamino-2-pentylamine

N‑[5‑(diethylamino)pentan‑2‑yl]‑4‑methyl‑6‑(4‑methylphenyl)pyrimidin‑2‑amine

N‑[5‑(diethylamino)pentan‑2‑yl]‑4‑methyl‑6‑(4‑methylphenyl)pyrimidin‑2‑amine

Conditions
ConditionsYield
In tetrahydrofuran at 120℃; for 13h; Microwave irradiation;81%

140-80-7Relevant articles and documents

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Neeman

, p. 811 (1946)

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Application of chiral chloroquine, hydroxychloroquine or salt of the chiral chloroquine and hydroxychloroquine as anti-coronavirus drug target 3CL hydrolase inhibitor for reducing cardiotoxicity

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, (2020/11/02)

The invention discloses an application of chiral chloroquine, hydroxychloroquine or pharmaceutically acceptable salts of the chiral chloroquine and hydroxychloroquine in preparation of drugs used forpreventing and/or treating coronavirus pneumonia by using a coronavirus key drug target 3CL hydrolase (Mpro) as an action target. The chiral chloroquine and hydroxychloroquine have high bonding strength with the Mpro causing inflammation of the lung and the like; the activity of the Mpro can be significantly inhibited; and the chiral chloroquine and hydroxychloroquine are indicated to have the effect of preventing and treating pneumonia caused by coronaviruses and be able to be used as anti-pneumonia drugs. Through evaluation on the inhibitory activity of an hERG potassium ion channel, the concentration at which the chloroquine, hydroxychloroquine and enantiomers of the chloroquine and hydroxychloroquine are likely to generate cardiotoxicity to the hERG potassium ion channel is provided. The chiral chloroquine and hydroxychloroquine are prepared through chiral high-performance liquid chromatography and chiral synthesis; S-configuration chloroquine, hydroxychloroquine or salts of the chloroquine and hydroxychloroquine can be selected as a drug independently, or form a pharmaceutical composition for treating diseases caused by the coronaviruses; and due to higher activity and low cardiotoxicity of the chloroquine, hydroxychloroquine or salts of the chloroquine and hydroxychloroquine, the administration dosage range is greatly widened.

2-aminopyridine derivatives and combinatorial libraries thereof

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, (2008/06/13)

The present invention relates to novel 2-aminopyridine derivative compounds of the following formula: wherein R1to R5have the meanings provided herein. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing 2-aminopyridine derivative compounds.

2'-(4,6-Disubstituted)-s-triazin-2-yl)amino-6'-dialkylamino flurans

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, (2008/06/13)

Fluorans useful as color precursors, particularly in the art of carbonless duplicating are normally colorless and are represented by the structural formula STR1 wherein R represents non-tertiary alkyl of one to four carbon atoms; R1 and R2 represent hydrogen or non-tertiary alkyl of one to four carbon atoms; R3 and R4 represent chlorine, NH2 or one of the groups --NR5 -(lower-alkylene)-N(R6)(R7), --NR5 -(lower-alkylene-N(R8)(R9)(R10) An, -NR5 -(lower-alkylene)-OH, -NR5 -(lower-alkylene) STR2 --NR5 -(HSO3 -C6 H4) or --O-(lower-alkylene)-N(R8)(R9) in which R5, R6 and R7 represent hydrogen or non-tertiary alkyl of one to four carbon atoms; R8 and R9 represent non-tertiary alkyl of one to four carbon atoms; R10 represents non-tertiary alkyl of one to four carbon atoms, benzyl or benzyl substituted in the benzene ring by one or two of halo or alkyl of one to three carbon atoms; and An represents an anion.

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