138402-05-8

Basic information

• Product Name: 2-N-BUTYL-1,3-DIAZA-SPIRO[4,4]NON-1-EN-4-ONE HYDROCHLORIDE
• Synonyms: 2-BUTYL-1,3-DIAZASPIRO[4.4]NON-1-EN-4-ONE HCL;2-BUTYL-1,3-DIAZASPIRO[4,4]NON-1-ENE-4-ONE HYDROCHLORIDE;2-N-BUTYL-1,3-DIAZA-SPIRO[4,4]NON-1-EN-4-ONE HCL;2-N-BUTYL-1,3-DIAZA-SPIRO[4,4]NON-1-EN-4-ONE HYDROCHLORIDE;2-N-BUTYL-1,3-DIAZA-SPIRO[4,4]NON-1-EN-4-ONE MONOHYDROCHLORIDE;2-Butyl-1,3-diazaspiro4.4non-1-en-4-one;2-Butyl-1,3-Diazaspiro[4,4]Non-1-En-4-One Hydrochloride;2-BUTYL-1,3-DIAZASPSPIRO[4,4]NON-1-EN-4-ONE
• CAS NO: 138402-05-8
• Molecular Formula: C₁₁H₁₈N₂O
• Molecular Weight: 194.28
• Product Categories: Heterocyclic Compounds;Heterocycles
• Mol File: 138402-05-8.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 294.7±23.0 °C(Predicted)
• Appearance: oil
• Density: 1.186 g/cm³
• Refractive Index: 1.592
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 6.42±0.20(Predicted)
• CAS DataBase Reference: 2-N-BUTYL-1,3-DIAZA-SPIRO[4,4]NON-1-EN-4-ONE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-N-BUTYL-1,3-DIAZA-SPIRO[4,4]NON-1-EN-4-ONE HYDROCHLORIDE(138402-05-8)
• EPA Substance Registry System: 2-N-BUTYL-1,3-DIAZA-SPIRO[4,4]NON-1-EN-4-ONE HYDROCHLORIDE(138402-05-8)

Safety Data

• Hazardous Substances Data: 138402-05-8(Hazardous Substances Data)

Usage

Description

2-N-Butyl-1,3-Diazaspiro[4,4]Non-1-En-4-One Hydrochloride is an organic compound that serves as an intermediate in the synthesis of pharmaceuticals. It is characterized by its oil-like chemical properties, which may contribute to its solubility and reactivity in various chemical processes.

Uses

Used in Pharmaceutical Industry:
2-N-Butyl-1,3-Diazaspiro[4,4]Non-1-En-4-One Hydrochloride is used as a chemical intermediate for the production of Irbesartan (Avapro) (I751000), which is a medication used to treat high blood pressure and type 2 diabetes. Its role in the synthesis process is crucial for the development of this medication, as it contributes to the overall structure and function of the final product.

InChI:InChI=1/C11H18N2O/c1-2-3-6-9-12-10(14)11(13-9)7-4-5-8-11/h2-8H2,1H3,(H,12,13,14)

Upstream product

• 1664-35-3 ethyl 1-aminocyclopentanecarboxylate 
• 999-09-7 ethyl valerimidate 
• 931-17-9 1,2-Cyclohexanediol 
• 18257-46-0 pentanamidine hydrochloride 
• 4524-93-0 Cyclopentanecarboxylic acid chloride 
• 638-29-9 n-valeryl chloride 
• 17193-28-1 1-aminocyclopentane-1-carboxamide 
• 177219-40-8 1-(pentanoylamino)cyclopentanecarboxamide 
• 151257-03-3 2-n-butyl-1,3-diazaspiro<4.4>nonan-4-one 
• 16195-83-8 1-aminocyclopentanecarbonitrile hydrochloride 
• 253269-07-7 (N-valeryl)-1-aminocyclopentanecarboxamide 

Downstream Products

• 138402-10-5 trityl irbesartan 
• 1029083-94-0 irbesartan trifluoroacetate 
• 960004-52-8 C₁₈H₂₃N₃O₃ 
• 1255948-69-6 2-(4-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-2-ethoxymethylphenyl)benzenesulfonic acid 
• 948349-73-3 3-[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-yl-methyl)-2-ethoxymethyl-phenyl]-5-methyl-thiophene-2-sulphonic acid (4,5-dimethyl-isoxazol-3-yl)-(2-methoxy-ethoxymethyl)-amide 
• 1003960-86-8 2-butyl-1-[(3'-(cyanomethoxy)biphenyl-4-yl)methyl]-4-spirocyclopentyl-1H-imidazol-5(4H)-one 
• 1003960-11-9 2-butyl-1-[(3'-((1-ethoxycarbonyl-1,1-dimethylmethyl)oxy)biphenyl-4-yl)methyl]-4-spirocyclopentyl-1H-imidazol-5(4H)-one 
• 1003960-12-0 1-[(6'-bromo-3'-((1-ethoxycarbonyl-1,1-dimethylmethyl)oxy)biphenyl-4-yl)methyl]-2-butyl-4-spirocyclopentyl-1H-imidazol-5(4H)-one 
• 138401-24-8 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile 
• 329055-20-1 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-n-butyl-4-spirocyclopentane-2-imidazolin-5-one hydrochloride 

Relevant articles and documents

OMS-2 nanorod-supported cobalt catalyst for aerobic dehydrocyclization of vicinal diols and amidines: Access to functionalized imidazolones

The development of reusable base metal catalysts for innovative catalytic transformations is a key technology toward sustainable production of fine chemicals, pharmaceuticals, and other function products. Herein, we report the preparation of a new highly dipersed manganese oxides of octahedral molecular sieve (OMS-2) nanorod-supported cobalt catalyst, which is successfully applied for aerobic dehydrocyclization of vicinal diols and amidines to access structurally diverse imidazolones, a class of valuable compounds found in numerous natural and biomedical products. The developed catalytic transformation proceeds with broad substrate scope, good functional group compability, the use of green molecular oxygen and reusable cobalt catalyst, which offers an important platform for the conversion of abundant and sustainable alcohol resources into functional N-heterocycles. The strategy combining nanocatalyst design with aerobic dehydrocoupling is anticipated to achieve other challenging catalytic transformations.

Synthesis of 2-Aminoimidazolones and Imidazolones by (3 + 2) Annulation of Azaoxyallyl Cations

The first examples of (3 + 2) annulations between azaoxyallyl cations and cyanamides and nitriles to give the corresponding 2-aminoimidazolones and imidazolones are reported. On the basis of the isolation of unexpected imidate products with certain substr

Oxidation of substituted imidazolidin-4-ones: New alternative method preparation of 4,5-dihydro-1H-imidazol-5-ones

The reaction of aldehydes (pentanal, benzaldehyde, 4-methoxybenzaldehyde, 4-nitrobenzaldehyde, salicylaldehyde, pyridin-2-carbaldehyde) with 1-aminocyclopentancarboxamide or (S)-2-amino-2,3-dimethylbutanamide has been used to prepare substituted imidazolidin-4-ones 1a-g (a: R1 = CH 3(CH2)3; b: R1 = C6H 5; c: R1 = 4-CH3OC6H4; d: R1 = 4-NO2C6H4; e: R1 = 2-HOC6H4; f: R1 = 2-pyridyl; for R2 = R3 = (CH2)4), and g: R1 = 2-pyridyl; for R2 = CH3; R3 = CH(CH 3)2) in the yields of 53-83%. Subsequent oxidations with various reagents gave the corresponding 4,5-dihydro-1H-imidazol-5-ones 2a-g: Pd/C (72-93%), DDQ (25-80%), and MnO2 (30-77%). Structure of the prepared compounds 1a-g and 2a-g was verified by 1H NMR and 13C NMR spectroscopy, EI-MS and elemental analysis. X-ray diffraction was performed in the case of compounds 1e and 2e.