1379596-14-1Relevant articles and documents
Synthesis and antibacterial activity of desosamine-modified macrolide derivatives
Letourneau, Nicolas,Vimal, Pavan,Klepacki, Dorota,Mankin, Alexander,Melman, Artem
, p. 4575 - 4578 (2012)
Structural factors behind erm macrolide resistance were studied through synthesis of new macrolide derivates possessing truncated desosamine sugar moieties and subsequent determination of their antibacterial activity. Synthesized compounds with 2′-deoxy a
An approach to the site-selective deoxygenation of hydroxy groups based on catalytic phosphoramidite transfer
Jordan, Peter A.,Miller, Scott J.
experimental part, p. 2907 - 2911 (2012/05/20)
Selective: The deoxygenation of simple and complex natural products employing a readily synthesized phosphoramidite and tetrazole catalysts can be executed as a two-step process, without the need to isolate intermediate deoxygenation precursors. Furthermore, a peptide-based tetrazole catalyst controls the site selectivity of deoxyerythromycin synthesis (see scheme), thus overcoming the notorious challenges with unprotected erythromycin A. Copyright
