13795-73-8 Usage
Description
(2S)-2-Aminobutanedioic acid ditert-butyl ester is a chemical compound with the molecular formula C10H19NO4. It is the di-tert-butyl ester of (2S)-2-aminobutanedioic acid, also known as serine. This derivative of the amino acid serine is commonly used in organic synthesis and as a building block for pharmaceutical intermediates. It is a white solid with a molecular weight of 221.26 g/mol and has a wide range of applications in the fields of chemistry and biochemistry.
Uses
Used in Organic Synthesis:
(2S)-2-Aminobutanedioic acid ditert-butyl ester is used as a reagent in organic synthesis for its ability to protect the amino group of serine during chemical reactions. This protection allows for selective reactions to occur at other sites on the molecule, facilitating the synthesis of complex organic compounds.
Used in Pharmaceutical Intermediates:
In the pharmaceutical industry, (2S)-2-Aminobutanedioic acid ditert-butyl ester serves as a key building block for the development of various drugs. Its protected structure enables the creation of novel drug candidates with specific therapeutic properties, contributing to the advancement of medicinal chemistry.
Used in Biochemical Research:
(2S)-2-Aminobutanedioic acid ditert-butyl ester is utilized in biochemical research as a protected form of serine. This allows researchers to study the role of serine in biological systems and enzymatic reactions without the complications of unwanted side reactions, thus enhancing the understanding of serine's biological functions and its potential applications in medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 13795-73-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,7,9 and 5 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 13795-73:
(7*1)+(6*3)+(5*7)+(4*9)+(3*5)+(2*7)+(1*3)=128
128 % 10 = 8
So 13795-73-8 is a valid CAS Registry Number.
13795-73-8Relevant articles and documents
Synthesis of Silacyclic Dipeptides: Peptide Elongation at Both N-And C-Termini of Dipeptide
Hattori, Tomohiro,Yamamoto, Hisashi
supporting information, p. 1758 - 1765 (2022/02/01)
A new type of peptide bond formation utilizing silacyclic amino acids or peptides is described. This work has the following advantages: (1) imidazolylsilane is a highly fascinating coupling reagent for dipeptide synthesis from N-,C-Terminal unprotected am
Synthesis of models of the BC ring systems of MPC1001 and MPC1001F
Dong, Shuai,Indukuri, Kiran,Clive, Derrick L. J.,Gao, Jin-Ming
supporting information, p. 8271 - 8274 (2016/07/06)
Piperazinedione 13, representing the BC rings of the anti-prostate cancer fungal metabolite MPC1001, was prepared by a route in which a sulfur-stabilized carbanion derived from 22 cyclizes onto the terminal ester of the pendant chain attached to N1. Another model, 14, was synthesized by cyclization of an α-ketoamide nitrogen onto an ester; 14 represents the BC rings of MPC1001F.
An efficient synthesis of tert-butyl ethers/esters of alcohols/amino acids using methyl tert-butyl ether
Mallesha,Prahlada Rao,Suhas,Channe Gowda
experimental part, p. 641 - 645 (2012/02/15)
A facile synthesis of a wide variety of tert-butyl ethers and tert-butyl ester derivatives under mild conditions is described. Alcohols etherified with tert-butyl methyl ether as tert-butyl source and solvent, in the presence of sulfuric acid. Many amino acid tert-butyl esters have been synthesized by this procedure. The reaction is simple, inexpensive, easily scaled up, and proceeds without observable racemization. A green method was developed for the deprotection of this group using Amberlite resin IR 120-H as catalyst.