1379473-99-0

Basic information

• Product Name: (1S,3'aR,4'aR,8'aR,9'aR,E)-2,2-dichloro-3'-(3,4-dimethoxybenzylidene)-8'a-methyldecahydro-2'H-spiro{cyclopropan-1,5'-naphtho[2,3-b]furan}-2'-one
• Synonyms: (1S,3'aR,4'aR,8'aR,9'aR,E)-2,2-dichloro-3'-(3,4-dimethoxybenzylidene)-8'a-methyldecahydro-2'H-spiro{cyclopropan-1,5'-naphtho[2,3-b]furan}-2'-one
• CAS NO: 1379473-99-0
• Molecular Weight: 451.39
• Mol File: 1379473-99-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1S,3'aR,4'aR,8'aR,9'aR,E)-2,2-dichloro-3'-(3,4-dimethoxybenzylidene)-8'a-methyldecahydro-2'H-spiro{cyclopropan-1,5'-naphtho[2,3-b]furan}-2'-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,3'aR,4'aR,8'aR,9'aR,E)-2,2-dichloro-3'-(3,4-dimethoxybenzylidene)-8'a-methyldecahydro-2'H-spiro{cyclopropan-1,5'-naphtho[2,3-b]furan}-2'-one(1379473-99-0)
• EPA Substance Registry System: (1S,3'aR,4'aR,8'aR,9'aR,E)-2,2-dichloro-3'-(3,4-dimethoxybenzylidene)-8'a-methyldecahydro-2'H-spiro{cyclopropan-1,5'-naphtho[2,3-b]furan}-2'-one(1379473-99-0)

Safety Data

• Hazardous Substances Data: 1379473-99-0(Hazardous Substances Data)

Upstream product

• 470-17-7 isoalantolactone 
• 1379473-95-6 (1S,3'aR,4'aR,8'aR,9'aR)-2,2-dichloro-8'a-methyl-3'-methylenedecahydro-2'H-spiro{cyclopropan-1,5'-naphtho[2,3-b]furan}-2'-one 
• 5460-32-2 1-iodo-3,4-dimethoxybenzene 

Relevant articles and documents

Synthetic transformations of sesquiterpene lactones. IV.* synthesis and transformations of gem-dichlorocyclopropyl-substituted isoalantolactone derivatives

Chloro-containing compounds, the ratio of which depended on the reaction time, were formed via reaction of isoalantolactone and CHCl3 through the action of a phase-transfer catalyst. 4,15-(2,2-Dichlorocycloprop-1-yl) isoalantolactone exhibited high activity and selectivity in the Heck reaction with arylhalides. Data for the cytotoxicity of the synthesized chloro-derivatives of isoalantolactone in CEM-13, MT-4, and U-937 cell tumor models were obtained. The doses of the most active compounds inhibiting the viability of tumor cells by 50% (CCID50) were 3.2-11.1 μM.