1377495-54-9

Basic information

• Product Name: methyl 6-(2-aminophenyl)-4-(1H-pyrrol-1-yl)hex-5-ynoate
• Synonyms: methyl 6-(2-aminophenyl)-4-(1H-pyrrol-1-yl)hex-5-ynoate
• CAS NO: 1377495-54-9
• Molecular Weight: 282.342
• Mol File: 1377495-54-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 6-(2-aminophenyl)-4-(1H-pyrrol-1-yl)hex-5-ynoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 6-(2-aminophenyl)-4-(1H-pyrrol-1-yl)hex-5-ynoate(1377495-54-9)
• EPA Substance Registry System: methyl 6-(2-aminophenyl)-4-(1H-pyrrol-1-yl)hex-5-ynoate(1377495-54-9)

Safety Data

• Hazardous Substances Data: 1377495-54-9(Hazardous Substances Data)

Upstream product

• 615-43-0 2-iodophenylamine 
• 1377495-51-6 methyl 4-(1H-pyrrol-1-yl)hex-5-ynoate 
• 1377495-48-1 methyl 5-(ethylthio)-5-oxo-4-(1H-pyrrol-1-yl)pentanoate 
• 1377495-45-8 5-methoxy-5-oxo-2-(1H-pyrrol-1-yl)pentanoic acid 
• 1377495-40-3 methyl 5-oxo-4-(1H-pyrrol-1-yl)pentanoate 
• 1499-55-4 DL-glutamic acid-5-methyl ester 

Downstream Products

• 1377495-57-2 5-[(2-aminophenyl)ethynyl]-6,7-dihydroindolizin-8(5H)-one 

Relevant articles and documents

Synthesis of the AB-DE ring system present in the alstoscholarine alkaloids

A practical protocol is presented for the construction of the AB-DE rings present in (19,20)-(E)- and (19,20)-(Z)-alstoscholarine alkaloids from the commercially available glutamic acid 5-methyl ester, employing only a six-step synthetic sequence. The main features include the synthesis of the alkynylindolizinone core and the use of Sonogashira cross-coupling and base-mediated cyclization to afford a 2-substituted indole without the use of protecting groups. Georg Thieme Verlag Stuttgart · New York.