1374146-76-5

Basic information

• Product Name: 4-neopentyl-2-phenyloxazol-5(4H)-one
• Synonyms: 4-neopentyl-2-phenyloxazol-5(4H)-one
• CAS NO: 1374146-76-5
• Molecular Weight: 231.294
• Mol File: 1374146-76-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-neopentyl-2-phenyloxazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-neopentyl-2-phenyloxazol-5(4H)-one(1374146-76-5)
• EPA Substance Registry System: 4-neopentyl-2-phenyloxazol-5(4H)-one(1374146-76-5)

Safety Data

• Hazardous Substances Data: 1374146-76-5(Hazardous Substances Data)

Upstream product

• 57224-50-7 (S)-2-Amino-4,4-dimethyl-pentanoic acid 
• 98-88-4 benzoyl chloride 
• 459836-81-8 N-benzoyl-L-β-tert-butylalanine 
• 459836-80-7 C₁₄H₁₉NO₃ 

Downstream Products

• 459836-80-7 C₁₄H₁₉NO₃ 
• 1562416-44-7 N-benzoyl-L-β-tert-butylalanine methyl ester 
• 1562416-45-8 C₁₅H₂₁NO₃ 

Relevant articles and documents

Peptide-catalyzed conversion of racemic oxazol-5(4 H)-ones into enantiomerically enriched α-amino acid derivatives

We report the development and optimization of a tetrapeptide that catalyzes the methanolytic dynamic kinetic resolution of oxazol-5(4H)-ones (azlactones) with high levels of enantioinduction. Oxazolones possessing benzylic-type substituents were found to perform better than others, providing methyl ester products in 88:12 to 98:2 er. The mechanism of this peptide-catalyzed process was investigated through truncation studies and competition experiments. High-field NOESY analysis was performed to elucidate the solution-phase structure of the peptide, and we present a plausible model for catalysis.