137-41-7Relevant articles and documents
Extractive spectrophotometric method for the determination of carbaryl in environmental samples
Sharma, Devender Kumar,Dharmani, Tilak,Sharma, Nisha
, p. 173 - 186 (2015)
In the view of the potential hazards associated with the widespread use of carbaryl insecticide, a new simple extractive spectrophotometric method has been developed for its determination in environmental samples viz. soil, water and foodstuffs for its safer and more effective use. The proposed method is based on the microwave assisted alkaline hydrolysis of the insecticide to methylamine. The later is measured as methyl isobutyl ketone (MIBK) extractable yellow nickel(II)-methyldithiocarbamate complex at 380 nm through the reaction with carbon disulfide and nickel(II) acetate. The insecticide can be determined in the linearity range from 2.01 to 60.3 μg mL-1 with a correlation coefficient of 0.996. The method has been applied to the analysis of carbaryl in its commercial formulation and its recovery from vegetable and water samples for monitoring health hazards. Recoveries of the insecticide from vegetables and spiked water samples were good, ranging from 87.6-92.8%, with RSDs ranging from 0.54-1.02%. The method has also been validated for investigating the sorption of carbaryl on five soils with different characteristics to evaluate its leaching behaviour which is a measure of ground and surface water contamination. The leaching potential of the insecticide in terms of groundwater ubiquity score (GUS) has values in the range 1.8-2.2 classifying it as transition leacher hence it has potential to contaminate groundwater.
Tetrahydro-2H-1,3,5-thiadiazine-5-(4-pyridylcarboxamide)-2-thione derivatives as prodrugs for isoniazid; synthesis, investigations and in vitro antituberculous activity.
Aboul-Fadl,Hassanin
, p. 244 - 247 (2007/10/03)
3-Substituted-5-(4-pyridylcarboxamido)tetrahydro-2H-1,3,5-thiad iazine-2- thione derivatives 5a-e were synthesized as prodrugs for isoniazid (INH) to overcome the resistance developed with its therapeutic use. These prodrugs revealed higher lipophilicity compared with INH. Their degradation kinetics were studied in vitro using aqueous buffer solutions of pH values 1.2 and 7.4 was well as biological media of human plasma and rat liver homogenate at 37 degrees C. They were more stable toward enzymatic degradation in biological than in chemical media. Release of INH from these derivatives was detected as a result of both chemical and enzymatic hydrolysis by HPLC. The antimycobacterial activity of the synthesized compounds and INH was tested in vitro against human type of Mycobacterium tuberculosis. They exhibited a greater antitubercular activity than the parent drug. This result is considered as an indicator for an improved permeation of the synthesized prodrugs through mycobacterial cell membranes relative to INH.
Synthesis and antimicrobial activities of some new tetrahydro-2H-1,3,5-thiadiazine-2-thione derivatives of ampicillin
Ertan,Tayhan,Yulug
, p. 605 - 609 (2007/10/02)
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