1354568-46-9Relevant articles and documents
Total Syntheses of rac- and (+)-Goniomitine
Park, Eunjoon,Cheon, Cheol-Hong
, p. 4888 - 4892 (2019)
Concise total syntheses of rac- and (+)-goniomitine were developed. The cyanide-catalyzed imino-Stetter reaction of an aldimine, derived from ethyl 2-aminocinnamate and either rac- or (S)-α,β-unsaturated aldehyde bearing a δ-valerolactam at the β-position
ASYMMETRIC CATALYTIC DECARBOXYLATIVE ALKYL ALKYLATION USING LOW CATALYST CONCENTRATIONS AND A ROBUST PRECATALYST
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Paragraph 0164, (2016/10/17)
This invention provides efficient and scalable enantioselective methods that yield 2-alkyl-2-allylcycloalkyanone compounds with quaternary stereogenic centers. Methods include the method for the preparation of a compound of formula (I): comprising treatin
Formal total syntheses of classic natural product target molecules via palladium-catalyzed enantioselective alkylation
Liu, Yiyang,Liniger, Marc,McFadden, Ryan M.,Roizen, Jenny L.,Malette, Jacquie,Reeves, Corey M.,Behenna, Douglas C.,Seto, Masaki,Kim, Jimin,Mohr, Justin T.,Virgil, Scott C.,Stoltz, Brian M.
, p. 2501 - 2512 (2015/02/19)
Pd-catalyzed enantioselective alkylation in conjunction with further synthetic elaboration enables the formal total syntheses of a number of "classic" natural product target molecules. This publication highlights recent methods for setting quaternary and tetrasubstituted tertiary carbon stereocenters to address the synthetic hurdles encountered over many decades across multiple compound classes spanning carbohydrate derivatives, terpenes, and alkaloids. These enantioselective methods will impact both academic and industrial settings, where the synthesis of stereogenic quaternary carbons is a continuing challenge.
